疟疾防控新策略:利用按蚊肠道共生菌阻断疟原虫传播  

New strategies for malaria control:using mosquito symbiotic bacteria to block malaria transmission

作　　者：蒋永茂 高涵 王四宝[1] JIANG Yong-mao;GAO Han;WANG Si-bao(CAS Key Laboratory of Insect Developmental and Evolutionary Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,Shanghai 200032,China)

机构地区：[1]中国科学院昆虫发育与进化生物学重点实验室,中国科学院分子植物科学卓越创新中心,中国科学院上海植物生理生态研究所,上海200032

出　　处：《中国寄生虫学与寄生虫病杂志》2022年第2期140-145,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(31830086,32021001)。

摘　　要：疟疾是一种由疟原虫感染引发的蚊媒传染病。由于缺乏高效的疫苗,目前疟疾防控主要依靠控制蚊虫的杀虫剂以及抗疟药物。然而,杀虫剂的滥用导致蚊虫产生抗药性、以及耐抗疟药物疟原虫株的出现和扩散,使疟疾防控面临严峻挑战。近年来疟疾防控进展缓慢,亟需发展新的防控策略和工具。利用肠道共生菌阻断疟原虫传播的技术是一种新型的源头防控策略,该策略近年来取得显著的进展。本文对该技术的发展及研究现状进行综述,并对应用该技术面临的挑战进行探讨。Malaria is a mosquito borne parasitic disease caused by Plasmodium infection.In the absence of highly effective vaccines,controlling malaria mainly relies on mosquito-controlling insecticides and antimalarial drugs.However,increased resistance to insecticides among mosquitoes and the emergence and spread of antimalarial drug-resistant parasites have become significant challenges in the fight against malaria.In recent years,global progress toward malaria prevention and control has remained stagnant,and new strategies to control malaria are urgently needed.Symbiotic control is a new strategy that uses mosquito gut symbiotic microorganisms to control vector mosquitoes or reduce vector competence.This strategy has made remarkable progress in recent years.Here,the advances in the development and research of this technology are reviewed,and the challenges in the application of symbiotic control of malaria are discussed.

关 键 词：疟疾 按蚊 疟原虫 共生菌 共生菌阻断技术 

分 类 号：R531.3[医药卫生—内科学]