感染蠕虫后宿主T细胞免疫应答相关信号通路的研究进展  

Research progress on signal pathways related to host T cell immune response in helminth infection

作　　者：何威 周必英 HE Wei;ZHOU Bi-ying(Department of Parasitology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学寄生虫学教研室,遵义563000

出　　处：《中国寄生虫学与寄生虫病杂志》2022年第2期223-227,235,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(81960378)。

摘　　要：蠕虫感染普遍存在于亚洲、非洲和南美洲,严重影响人类健康和经济发展。蠕虫感染可启动宿主T细胞免疫应答,影响T细胞增殖与分化。宿主感染蠕虫后,转化生长因子-β/Smad、诱导共刺激分子-诱导共刺激分子配体、程序性死亡蛋白-1/程序性死亡蛋白-1配体、Toll样受体/髓样分化因子88等信号通路可参与T细胞免疫应答,信号分子相互作用可诱导T细胞增殖与分化,进而影响宿主T细胞发挥抗蠕虫感染的作用。本文就宿主感染蠕虫后T细胞免疫应答相关信号通路的研究进展进行综述。Helminthiasis is highly prevalent in Asia,Africa and South America,seriously affecting human health and economic development.Helminths infection can initiate host T cell immune response,thereby affecting T cell proliferation and differentiation.Some data indicate that in helminth infection,signalling pathways including transforming growth factor-β/Smad(TGF-β/Smad),inducible costimulator-inducible costimulator ligands(ICOS-ICOSL),programmed cell death protein-1/programmed death protein-1 ligand(PD-1/PD-L1),toll-like receptors/myeloid differentiation factor 88(TLRs/MyD88).can participate in host T cell immune response,the interaction between signalling molecules can induce T cell proliferation and differentiation,then affect the host T cells to play an role in anti-worm infection effect.This article has reviewed the research advances on T cell immune response-related signalling pathways in worm infection.

关 键 词：蠕虫 细胞免疫应答 信号通路 

分 类 号：R383[医药卫生—医学寄生虫学]