S-腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床疗效观察  

Clinical efficacy of S-adenosylmethionine combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy and its influence on liver function and inflammatory factors

作　　者：李婷婷 Li Tingting(The Kuitun Maternal and Child Health and Family Planning Service Center,YiLi Kazak Autonomous Prfectuve,YiLi,Xinjiang,833200)

机构地区：[1]新疆维吾尔自治区伊犁哈萨克自治州奎屯市妇幼保健计划生育服务中心,新疆伊犁833200

出　　处：《基层医学论坛》2022年第22期16-18,共3页The Medical Forum

摘　　要：目的探讨S-腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效及对肝功能、炎症因子的影响。方法选择新疆维吾尔自治区伊犁哈萨克自治州奎屯市妇幼保健计划生育服务中心于2018年7月—2020年7月间收治的54例妊娠肝内胆汁淤积症产妇为研究资料,依照治疗方案差异将其分为常规、联合2组。常规组27例患者,接受常规方案治疗;联合组27例患者,接受S-腺苷蛋氨酸联合熊去氧胆酸方案治疗,分析对比2组产妇的治疗效果、肝功能、炎症因子。结果联合组产妇症状消退时间(3.17±0.29)d明显短于常规组(5.84±0.42)d(t=27.18,P<0.05);其治疗后第5日症状评分(0.67±0.24)分低于常规组(1.53±0.22)分(t=15.32,P<0.05)。治疗前2组肝功能无明显差异,治疗后联合组TBA、AST、AST分别为(14.56±3.83)μmol/L、(56.02±9.63)U/L、(48.88±7.17)U/L,明显低于常规组(P<0.05)。联合组IL-12、IL-18水平低于常规组,差异具有统计学意义(P<0.05)。结论对妊娠肝内胆汁淤积症产妇使用S-腺苷蛋氨酸和熊去氧胆酸联合方案治疗,可有效缓解患者不适症状、提升肝功能水平,改善其体内炎性因子水平,降低妊娠期风险,值得在临床上推广使用。Objective To investigate the clinical efficacy of S-adenosylmethionine combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy(ICP)and its influence on liver function and inflammatory factors.Methods 54 pregnant women with intrahepatic cholestasis of pregnancy in our hospital from July 2018 to July 2020 were selected as the research data,and they were divided into routine group and combined group according to the difference of treatment schemes.There were 27 patients in the conventional group,who received conventional treatment;27 patients in the combined group,who received S-adenosylmethionine combined with ursodeoxycholic acid treatment.The therapeutic effect,liver function and inflammatory factors of the two groups were analyzed and compared.Results The time of symptoms subsided in the combined group was(3.17±0.29)d,which was significantly shorter than that in the conventional group(5.84±0.42)d,(t=27.18,P<0.05);the symptom score on the 5th day after treatment was lower(0.67±0.24),which was lower than that in the conventional group(1.53±0.22),t=15.32,(P<0.05).After treatment,TBA,AST and AST parameter levels of the combined group were(14.56±3.83)μmol/L,(56.02±9.63)U/L and(48.88±7.17)U/L respectively,which were significantly lower than those of the conventional group(P<0.05).Compared with the changes of inflammatory factors,the levels of IL-12 and IL-18 in the combined group were lower than those in the conventional group,with statistical significance(P<0.05).Conclusion The combination of S-adenosylmethionine and ursodeoxycholic acid in the treatment of pregnant women with intrahepatic cholestasis of pregnancy can effectively alleviate the discomfort symptoms of patients,improve the level of liver function,improve the level of inflammatory factors in the body,and reduce the risk of pregnancy,which is worthy of clinical application.

关 键 词：妊娠肝内胆汁淤积症(ICP) S-腺苷蛋氨酸 熊去氧胆酸 临床疗效 

分 类 号：R3[医药卫生—基础医学]