超声引导下星状神经节阻滞联合盐酸乙哌立松治疗颈源性头痛的临床研究  

Clinical study of ultrasound-guided stellate ganglion block combined with eperisone hydrochloride in the treatment of cervicogenic headache

作　　者：万瑞莲 浦少峰 王建光[1] WAN Rui-lian;PU Shao-feng;WANG Jian-guang(Department of Pain,South Hospital,the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 201400,China;Department of Pain,the Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China)

机构地区：[1]上海交通大学附属第六人民医院南院疼痛科,上海201400 [2]上海交通大学附属第六人民医院疼痛科,上海200030

出　　处：《临床和实验医学杂志》2022年第11期1218-1222,共5页Journal of Clinical and Experimental Medicine

基　　金：上海市卫生健康委员会先进适宜技术推广项目(编号:2019SY051)。

摘　　要：目的探究超声引导下星状神经节阻滞联合盐酸乙哌立松治疗颈源性头痛的临床研究。方法回顾性选取2019年3月至2020年3月上海交通大学附属第六人民医院南院疼痛科收治的60例颈源性头痛患者为研究对象,根据不同治疗方法将患者分为观察组(n=32)与对照组(n=28)。对照组使用超声引导下星状神经节组滞治疗,观察组则在对照组基础上给予盐酸乙哌立松治疗。观察两组患者治疗前后证状评分、医学结局研究用疼痛量表(MOSPM)、视觉模拟评分法(VAS)评分、生活质量评分(CHQOL)、C反应蛋白(CRP)、白细胞介素(IL)-4、IL-6及红细胞沉降率(ESR)、头痛发作次数、颈椎活动度和治疗后临床疗效与不良发应发生率。结果治疗前,两组患者VAS评分、MOSPM评分比较,差异均无统计学意义(P>0.05);治疗后,观察组患者VAS评分、MOSPM评分均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者上肢痛、颈项痛、条索样阳性反应物、棘突旁压痛、头晕、失眠和工作能力评分比较,差异均无统计学意义(P>0.05);治疗后,观察组上肢痛、颈项痛、条索样阳性反应物、棘突旁压痛、头晕、失眠和工作能力评分均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组颈椎活动度与疼痛次数比较,差异无统计学意义(P>0.05);治疗后,观察组颈椎活动度与疼痛次数均较对照组显著降低,差异均有统计学意义(P<0.05)。治疗前,两组患者IL-4、IL-6、ESR、CRP水平比较,差异均无统计学意义(P>0.05);治疗后,观察组IL-4、IL-6、ESR、CRP水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者CHQOL比较,差异无统计学意义(P>0.05);治疗后,观察组CHQOL评分高于对照组,差异有统计学意义(P<0.05)。观察组总有效率为93.75%,显著高于对照组(74.99%),差异有统计学意义(P<0.05)。结论超声引导下星状神经节阻滞联合盐酸乙哌立松能有�Objective To investigate the clinical efficacy of ultrasound-guided stellate ganglion block combined with eperisone hydrochloride in the treatment of cervicogenic headache.Methods Sixty patients with cervicogenic headache in the Department of Pain,South Hospital,the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University from March 2019 to March 2020 were retrospectively enrolled,and divided into observation group(n=32)and control group(n=28)by different treatment methods.The control group received ultrasound-guided stellate ganglion block,while the observation group received ultrasound-guided stellate ganglion block combined with eperisone hydrochloride.Then the symptoms score,Medical Outcomes Study Pain Measurement(MOSPM)score,visual analogue scale(VAS)score,Chinese Quality of Life Scale(CHQOL),C-reactive protein(CRP),interleukin(IL)-4,IL-6,and,erythrocyte sedimentation rate(ESR),frequency of headache attacks,range of motion of the cervical spine,the clinical efficacy and incidence of adverse events were compared between two groups.Results Before treatment,there was no significant difference in VAS score and MOSPM score between the two groups(P>0.05);after treatment,the VAS score and MOSPM score of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in upper limb pain,neck pain,immunoreactive nerve fibers,paravertebral pressure,dizziness,insomnia and work ability denoted scores between the two groups(P>0.05);after treatment,the upper limb pain,neck pain,cord-like positive reactants,paraspinous tenderness,dizziness,insomnia and work ability scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in cervical spine activity and pain frequency between the two groups(P>0.05);after treatment,the cervical spine activity and pain frequency in the observati

关 键 词：颈源性头痛 超声引导下星状神经节阻滞 盐酸乙哌立松 

分 类 号：R681.5[医药卫生—骨科学]