破伤风特异性免疫对献血浆者体内循环免疫复合物含量的影响  

Effect of tetanus specific immunization on circulating immune complexes in plasma donors

作　　者：高允鹏 陈祥文 翟朝浩 邵玉娟 张峰 Gao Yunpeng;Chen Xiangwen;Zhai Chaohao;Shao Yujuan;Zhang Feng(Blood Source Management Center,Shandong Taibang Biological Product Co.,Ltd.,Taian 271000,China)

机构地区：[1]山东泰邦生物制品有限公司血源管理中心,泰安271000

出　　处：《国际生物制品学杂志》2022年第2期81-84,共4页International Journal of Biologicals

基　　金：上海市"科技创新行动计划"生物医药领域科技支撑项目(18431905900)。

摘　　要：目的通过检测献血浆者血浆中循环免疫复合物(circulating immune complex, CIC)补体成分3d(complement component 3d, C3d)含量, 分析破伤风特异性免疫对献血浆者CIC含量的影响。方法选取2020年8月25日至9月4日期间, 在山东省夏津泰邦单采血浆站和山亭泰邦单采血浆站的献血浆者, 分为普通组、常规免疫组和强化免疫组, 采用CIC-C3d ELISA试剂检测献血浆者血浆CIC-C3d含量。结果 3组献血浆者CIC-C3d浓度均<16 μg/ml, 3组献血浆者CIC-C3d浓度间差异无统计学意义(F=1.00, P=0.37)。结论破伤风特异性免疫对献血浆者体内CIC浓度无明显影响。Objective To analyze the effect of tetanus specific immunization on the content of circulating immune complex(CIC)in plasma donors by detecting the content of CIC-complement component 3d(C3d)in plasma.Method Plasma donors from Xiajin Taibang plasma collection station and Shanting Taibang plasma collection station in Shandong Province from August 25 to September 4,2020 were divided into normal group,routine immunization group and intensive immunization group.The plasma CIC-C3d content of plasma donors was detected by CIC-C3d ELISA reagent.Results The concentration of CIC-C3d in plasma donors of the three groups was less than 16μg/ml.There was no statistically significant difference in CIC-C3d concentration among the three groups(F=1.00,P=0.37).Conclusion Tetanus specific immunization has no significant effect on CIC concentration in plasma donors.

关 键 词：特异性献血浆者 循环免疫复合物 免疫复合物病 辅助诊断 酶联免疫吸附测定 补体成分3d 

分 类 号：R97[医药卫生—药品]