精准氧化还原调控  

Precision redox regulation

作　　者：陈畅[1,2] CHEN Chang(National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院生物物理研究所,生物大分子国家重点实验室,北京100101 [2]中国科学院大学,北京100049

出　　处：《药学学报》2022年第6期1541-1543,I0004,共4页Acta Pharmaceutica Sinica

基　　金：国家重点研发计划(2017YFA0504000);国家自然科学基金资助项目(91849203,31570857);中国科学院先导计划(XDB39000000)。

摘　　要：生命离不开氧,氧化还原应激是细胞信号转导的重要调控方式,介导衰老、神经退行性疾病、代谢病、肿瘤等许多生理和病理过程。氧化还原平衡调控是促进生命健康的重要方面。本文分析了抗氧化剂研发和应用中长期面临的挑战和背后的三方面主要原因:对氧化还原应激的生理功能认识不足;抗氧化过度,引起还原应激;抗氧化策略缺乏特异性和精准性。作者提出细胞和机体具有精准氧化还原属性,抗氧化等氧化还原干预策略要考虑五个合适,即:合适的干预分子、时间、空间、水平、靶点,简称“5R”原则(right species、right time、right place、right level、right target)。精准氧化还原调控是未来发展方向,精准氧化还原医药研发正在开启。Oxygen is vital for life.Redox stress is important in cell signal transduction,mediating many physiological and pathological processes such as aging,neurodegenerative diseases,metabolic diseases and tumors.Redox homeostasis maintainance is critical for promoting life health.In this paper,the lasting challenges during antioxidant research and development and the beyond main reasons were analyzed:including insufficient understanding of the physiological function of redox stress;excessive antioxidant,causing reductive stress;antioxidant strategies lacking specificity.Here the author proposed that cells and the body own precise redox nature,therefore,redox intervention strategies such as anti-oxidation should consider the"5R"principle,i.e.right species,right time,right place,right level,right target.Precision redox regulation is the future direction and precise redox medicine development is opening.

关 键 词：氧化还原应激 氧化应激 还原应激 氧化还原调控 抗氧化剂 精准氧化还原调控 精准氧化还原医药 5R 

分 类 号：R966[医药卫生—药理学]