百两金中一个新的γ-戊内酯衍生物  

A new γ-valerolactone derivative from the roots of Ardisia crispa

作　　者：殷鑫 胡瑞航 周永强 魏鑫 朱蔚芊 俸婷婷 周英 YIN Xin;HU Rui-hang;ZHOU Yong-qiang;WEI Xin;ZHU Wei-qian;FENG Ting-ting;ZHOU Ying(College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025

出　　处：《药学学报》2022年第6期1845-1848,共4页Acta Pharmaceutica Sinica

基　　金：国家重点研发计划(2018YFC1708100);国家自然科学基金项目(82104538);贵州省科技计划项目(黔科合平台人才[2019]5407);贵州省教育厅青年人才成长项目(黔教合KY [2021]202);贵州省科技厅基础研究计划(黔科合基础-ZK [2021]一般519)。

摘　　要：采用正相硅胶柱色谱、反相ODS柱色谱、HPLC高效液相色谱法对百两金乙醇提取物进行分离纯化,结合理化性质、UV、MS、NMR等波谱学技术鉴定化合物的结构。从百两金提取物乙酸乙酯部位中分离鉴定出4个单体化合物,分别为百两金内酯A (1)、(+)-pinoresinol (2)、3,5-二甲氧基-4羟苯基-1-O-β-D-吡喃葡萄糖苷(3)和(+)-schizandriside (4),其中化合物1为新化合物,化合物2~4为首次从该植物中分离得到。Four compounds were isolated from the 70% EtOH extract of Ardisia crispa by using various chromatographic techniques, including silica gel, ODS and semi-preparative HPLC. The structures of 1-4 were elucidated based on physicochemical properties and spectroscopic data. These compounds were defined as crispalactone A(1),(+)-pinoresinol(2), 3,5-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside(3) and(+)-schizandriside(4). Compound 1 is a new γ-valerolactone derivative, and compounds 2-4 are firstly isolated from Ardisia crispa.

关 键 词：报春花科 百两金 γ-戊内酯 化学成分 

分 类 号：R284[医药卫生—中药学]