靶向肠道菌群防治新型冠状病毒肺炎  

Targeting gut microbiota modulation for preventing and treating the COVID-19

作　　者：张伟[1] 吕媛媛 刘海霞 李宗杰 ZHANG Wei;LYU Yuanyuan;LIU Haixia;LI Zongjie(Rizhao Disease Control and Prevention Center of Shandong Province,Rizhao 276827,China;Rizhao Maternal and Child Health Hospital,Rizhao 276827,China;Beijing Huayuan Biotechnology Research Institute,Beijing 100023,China;Shanghai Institute of Veterinary Medicine,Chinese Academy of Agricultural Sciences,Shanghai 200241,China)

机构地区：[1]山东省日照市疾病预防控制中心,日照276827 [2]日照市妇幼保健院,日照276827 [3]北京华元生物技术研究院,北京100023 [4]中国农业科学院上海兽医研究所,上海200241

出　　处：《生命的化学》2022年第1期20-26,共7页Chemistry of Life

基　　金：国家自然科学基金项目(31672606)。

摘　　要：自2019年12月发现严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)以来,由其引起的新型冠状病毒肺炎(COVID-19)在全球范围内的肆意传播已经引起大量人员感染和死亡。由于SARS-CoV-2病毒结构的特殊性,导致其在体内复制的过程中非常容易发生突变,毒力更强和传播性更强的变异毒株加剧了疫情的扩散。实际上,COVID-19患者不仅会出现咳嗽、打喷嚏、呼吸急促和发烧等呼吸道相关的症状,还有相当比例的患者也会出现恶心、腹痛和腹泻等症状,表明COVID-19患者的症状严重程度与肠道菌群有密切关系。SARS-CoV-2病毒感染后会导致肠道内细菌、真菌和病毒的结构组成发生变化。因此,通过饮食干预、补充益生菌和益生元、进行粪菌移植以及中医药治疗等干预措施有助于维持肠道微生态平衡。该文主要综述了COVID-19的临床特点和病理学特征、患者的消化道症状、肠道菌群变化以及靶向肠道菌群的预防和治疗等方面的研究进展,以期为防治COVID-19提供新策略和新靶点。Since the emergence of SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)virus in December 2019,the rapid worldwide spread of COVID-19(coronavirus disease 2019)has caused a large number of human infections and deaths.Due to the special structure of SARS-CoV-2 virus,it is very easy to mutate in the process of replication in vivo.The mutant strains with stronger virulence and transmission accelerate the transmission speed of the COVID-19 epidemic.In fact,patients with COVID-19 not only have respiratory symptoms such as cough,sneezing,shortness of breath and fever,but also have gastrointestinal symptoms such as nausea,abdominal pain and diarrhea,indicating that the symptoms severity of COVID-19 patients is closely related to intestinal flora.A large number of studies have confirmed that SARS-CoV-2 virus infection could change the structure and composition of intestinal bacteria,fungi and viruses.Therefore,intervention measures such as dietary intervention,supplementation of probiotics and prebiotics,fecal bacteria transplantation and traditional Chinese medicine treatment are helpful to maintain intestinal microecological balance.This review mainly summarize the research progress of COVID-19 clinical and pathological characteristics,gastrointestinal symptoms,intestinal flora changes and treatment targeted intestinal flora of COVID-19 patients,in order to provide new strategies and new targets for the prevention and treatment of COVID-19.

关 键 词：新型冠状病毒肺炎 肠道菌群 微生态平衡 益生菌 

分 类 号：R563.1[医药卫生—呼吸系统]