小清蛋白阳性神经元调节睡眠-觉醒的研究进展  

Recent advance in sleep-wake regulation of parvalbumin positive neurons

作　　者：罗丹 易如岚 张宇 Luo Dan;Yi Rulan;Zhang Yu(College of Graduate School,Zunyi Medical University,Zunyi 563099,China;Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563099,China)

机构地区：[1]遵义医科大学研究生院,遵义563099 [2]遵义医科大学附属医院麻醉科,遵义563099

出　　处：《中华神经医学杂志》2022年第6期619-623,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(82060262)。

摘　　要：小清蛋白(PV)阳性神经元是γ-氨基丁酸(GABA)能抑制性中间神经元的主要亚型之一,广泛分布于各个脑区。既往研究发现PV阳性神经元与癫痫、精神分裂症、抑郁症、孤独症、老年痴呆症、共济失调、吗啡依赖及戒断等密切相关,新近研究发现PV阳性神经元在睡眠-觉醒调节中同样发挥着重要作用,这意味着PV阳性神经元在全麻致意识消失及意识恢复过程中也有着重要作用。笔者现围绕PV阳性神经元的生物学特征及其在不同脑区调节睡眠-觉醒的研究进展进行综述,以期为全麻致意识消失及意识恢复的机制研究提供新的思路。Parvalbumin(PV)positive neurons,as one of the most important subtypes ofγ-aminobutyric acid(GABA)inhibited interneurons,are widely distributed in various brain regions.Previous studies have found that PV positive neurons are closely related to epilepsy,schizophrenia,depression,autism,Alzheimer's disease,ataxia,and morphine dependence and withdrawal.However,recent studies have found that PV positive neurons also play an important role in sleep-wake regulation,suggesting that PV positive neurons may also play an important role in the process of consciousness loss and consciousness recovery induced by general anesthesia.This review focuses on the biological characteristics of PV positive neurons and the research progress of sleep-wake regulation in different brain regions,in order to provide new ideas for the study of mechanism of consciousness loss and consciousness recovery induced by general anesthesia.

关 键 词：小清蛋白阳性神经元 睡眠-觉醒 基底前脑 丘脑网状核 大脑皮层 

分 类 号：R338[医药卫生—人体生理学]