Practical and modular construction of benzo[c]phenanthridine compounds  

作　　者：Cheng Zhang Qian Chen Lei Wang Qiaoying Sun Yangyang Yang Matthias Rudolph Frank Rominger A.Stephen K.Hashmi 

机构地区：[1]Organisch-Chemisches Institut,Heidelberg University,Heidelberg 69120,Germany [2]Chemistry Department,Faculty of Science,King Abdulaziz University(KAU),Jeddah 21589,Saudi Arabia [3]Cellular Immunotherapy Lab,the Medical Faculty of Heidelberg University,Heidelberg University Hospital,Heidelberg 69120,Germany

出　　处：《Science China Chemistry》2022年第7期1338-1346,共9页中国科学（化学英文版）

摘　　要：Here,we describe a general and modular strategy for the rapid assembly of benzo[c]phenanthridine(BCP)derivatives using homogeneous gold catalysis.Notably,in contrast to traditional methods based on the specially preformed substrates that have an inherent preference for the formation of this class of compounds with limited flexibility,this protocol is achieved via a selectively intramolecular cascade of a diazo-tethered alkyne and subsequently an intermolecular cyclization with a nitrile to facilitate the successive C–N and C–C bonds formation.This methodology uses readily available nitriles as the nitrogen source to deliver the products in good yield with excellent functional group compatibility.A preliminary anti-tumor activity study of these generated products exhibits high anticancer potency against five tumor cell lines,including He La,Mel624,SW-480,8505C,LAN-1.Besides,we report a catalyst-controlled intermolecular cycloaddition/intramolecular insertion of the substrate with a fulvene to provide fused polycarbocycles containing a seven-membered ring.

关 键 词：SELECTIVITY homogeneous gold catalysis domino cyclization benzo[c]phenanthridine(BCP) anticancer activity 

分 类 号：O626[理学—有机化学]