抗生素佐剂与抗生素联用的抑菌作用研究进展  

Research Progress in Antibiotic Adjuvant and Antibiotics in Antibacterial Aspects

作　　者：朱浩 张严伟[3] 刘润 梁艳 杨奕[4] 徐天乐 杨章平 ZHU Hao;ZHANG Yan-wei;LIU Run;LIANG Yan;YANG Yi;XU Tian-le;YANG Zhang-ping(Joint International Research Laboratory of Agriculture and Agri-Product Safety,Ministry of Education of China,Yangzhou University,Yangzhou 225009;College of Animal Science and Technology,Yangzhou University,Yangzhou 225000;Jiangsu Provincial Agricultural Reclamation and Development Corporation,Nanjing 210019;College of Veterinary Medicine,Yangzhou University,Yangzhou 225000)

机构地区：[1]扬州大学农业科技发展研究院,扬州225000 [2]扬州大学动物科学与技术学院,扬州225000 [3]江苏省农垦集团有限公司,南京210019 [4]扬州大学兽医学院,扬州225000

出　　处：《生物技术通报》2022年第6期66-73,共8页Biotechnology Bulletin

基　　金：江苏省现代农业产业(奶牛)技术体系首席专家项目(JATS[2021]486);国家自然科学基金青年项目(32102731);江苏省基础研究计划(自然科学基金)(BK20190881);江苏省农业自主创新资金(CX(20)3089)。

摘　　要：细菌耐药性一直是一项全球性的卫生挑战,加剧人们控制和治疗危及生命的细菌感染难度。尽管人们正在努力开发新的抗生素或其替代品,但在过去的二十多年,几乎没有新的抗生素或其替代品被临床批准使用。抗生素佐剂与抗生素的组合可以抑制细菌耐药性或增强抗生素抑菌性,为对抗多重耐药细菌提供了一种可持续和有效的策略。本文综述了抗生素佐剂的分类和作用机制。最后讨论了抗生素佐剂和抗生素联合使用策略的发展趋势和面临的挑战。Antimicrobial resistance has been a global health challenge,which increases the difficulty of controlling and treating lifethreatening bacterial infections.Despite ongoing efforts to identify new drugs or alternatives to antibiotics,no new classes of antibiotic or their alternatives have been clinically approved in the last two decades.A combination of antibiotic adjuvants and antibiotics inhibit bacterial resistance determinants or restore antibiotic sensitivity,and offer a sustainable and effective strategy to combat multidrug-resistant bacteria.The current review summarizes the classification and mechanism of antibiotic adjuvants,as well as discusses the challenges and development trends of antibiotic adjuvant and antibiotic combination strategy.

关 键 词：抗菌增效剂 抗生素 耐药性 协同作用 

分 类 号：R446.5[医药卫生—诊断学]