超重与肥胖对心血管疾病归因负担研究  

Burden of cardiovascular diseases attributable to overweight and obesity

作　　者：田奕欣 亢玉婷 曹雪 张林峰 陈祚 王馨 郑聪毅 陈露 周好奇 王增武 Tian Yixin;Kang Yuting;Cao Xue;Zhang Linfeng;Chen Zuo;Wang Xin;Zheng Congyi;Chen Lu;Zhou Haoqi;Wang Zengwu(Department of Community Control,Fuwai Hospital,Chinese Academy of Medical Sciences,National Center for Cardiovascular Diseases,Beijing 102308,China;Beijing Hospital,Beijing 100005,China)

机构地区：[1]中国医学科学院阜外医院国家心血管病防治中心社区防治部,北京102308 [2]北京医院,北京100005

出　　处：《心脑血管病防治》2022年第2期11-14,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：“十三五”国家重点研发计划项目(2018YFC1315303);“十二五”国家科技支撑计划(2011BAI11B01)。

摘　　要：目的 分析心血管疾病归因于超重、肥胖人群的归因负担。方法 从中国高血压调查中选取35岁及以上研究对象的基线资料和随访的心血管结局事件。采用人群归因百分比(PAF)评估超重、肥胖造成的全国及各省份心血管疾病负担。结果 在平均4.56年的随访中,有349例冠心病事件和672例脑卒中事件发生。在全国层面,超重和肥胖对心血管疾病的PAF分别为6.20%(95%CI=6.16~6.24)和7.08%(95%CI=6.99~7.17),对冠心病的PAF分别为6.84%(95%CI=6.80~6.89)和10.78%(95%CI=10.65~10.90),脑卒中PAF分别为8.72%(95%CI=8.66~8.78)和6.96%(95%CI=6.87~7.04)。对于各省而言,北方地区PAF较高,南方地区PAF较低。结论 中国心血管疾病很大比例可归因于肥胖,且不同地区存在显著差异。Objective To analyze the results of the attribution burden of cardiovascular disease(CVD) to overweight and obesity. Methods Baseline data and follow-up cardiovascular outcomes of subjects aged 35 years and older were selected from the Chinese Hypertension Survey.Population attributable fraction(PAF) was used to assess the burden of CVD caused by overweight and obesity in China and 31 provinces. Results During a mean follow-up of 4.56 years, 349 coronary heart diseases and 672 strokes occurred. At national level, the PAF of CVD was 6.20% [95%(CI)=6.16-6.24] for overweight, 7.08%(95%CI=6.99-7.17) for obesity;for coronary heart disease, 6.84%(95%CI=6.80-6.89) and 10.78%(95%CI=10.65-10.90);for stroke, 8.72%(95%CI=8.66-8.78) and 6.96%(95%CI=6.87-7.04). At province level, the PAF was higher in north provinces lower in south provinces. Conclusion There are strikingly different across geographic regions, with a large proportion of CVD in China are attributable to obesity.

关 键 词：疾病负担 心血管疾病 冠心病 脑卒中 人群归因百分比 

分 类 号：R589.2[医药卫生—内分泌]