维生素E联合二甲双胍治疗对多囊卵巢综合征不孕症患者的影响  

Effect of vitamin E combined with metformin in infertility patients with polycystic ovary syndrome

作　　者：栗凤霞 王艳硕 史艳想 刘林林 冯玉环[3] LI Fengxia;WANG Yanshuo;SHI Yanxiang;LIU Linlin;FENG Yuhuan(Department of Gynecology,Xingtai Maternal and Child Health Hospital in Hebei Province,Xingtai,Hebei,054000;Department of Obstetrics and Gynecology,Shenzhou Hospital of Hebei Province,Hengshui,Hebei,053800;Reproductive Medicine Center,Tangshan Maternal and Child Health Hospital of Hebei Province,Tangshan,Hebei,063000)

机构地区：[1]河北省邢台市妇幼保健院妇科,河北邢台054000 [2]河北省深州市医院妇产科,河北衡水053800 [3]河北省唐山市妇幼保健院生殖医学中心,河北唐山063000

出　　处：《实用临床医药杂志》2022年第14期97-100,104,共5页Journal of Clinical Medicine in Practice

基　　金：河北省医学科学研究计划(20201483)。

摘　　要：目的探讨维生素E联合二甲双胍治疗对多囊卵巢综合征(PCOS)不孕症患者的影响。方法选取120例PCOS不孕症患者为研究对象,随机分为对照组60例和联合组60例。2组均进行基础治疗,对照组在此基础上使用二甲双胍进行治疗,联合组在对照组的基础上给予维生素E进行治疗。观察2组治疗前后胰岛素样生长因子-1(IGF-1)、单核细胞趋化蛋白-1(MCP-1)、性激素、氧化应激水平、子宫内膜厚度、卵巢体积。比较2组治疗总有效率、排卵率和妊娠率。结果治疗后,2组IGF-1、MCP-1、黄体生成素(LH)、卵泡刺激素(FSH)、LH/FSH、睾酮(T)低于治疗前,联合组低于对照组,差异有统计学意义(P<0.05)。联合组超氧化物歧化酶(SOD)、总抗氧化态(TAS)高于对照组,血清总氧化态(TOS)低于对照组,差异有统计学意义(P<0.05)。联合组子宫内膜厚度大于对照组,卵巢体积小于对照组,差异有统计学意义(P<0.05)。联合组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。联合组排卵率为80.00%,高于对照组的50.00%,差异有统计学意义(P<0.05);联合组妊娠率为50.00%,高于对照组的13.33%,差异有统计学意义(P<0.05)。结论采用维生素E联合二甲双胍治疗PCOS不孕症患者效果较好,可降低患者IGF-1、MCP-1水平,改善性激素水平、氧化应激水平,促进患者恢复。Objective To investigate the effect of vitamin E combined with metformin in infertility patients with polycystic ovary syndrome(PCOS).Methods A total of 120 PCOS infertile patients were selected as research objects,and randomly divided into control group(60 cases)and combined group(60 cases).Both groups received basic treatment,the control group was additionally treated with metformin,and the combined group was additionally treated with vitamin E.Insulin-like growth factor-1(IGF-1),monocyte chemoattractant protein-1(MCP-1),sex hormone,oxidative stress level,endometrial thickness and ovarian volume were observed before and after treatment in two groups.The total effective rate,ovulation rate and pregnancy rate were compared between the two groups.Results After treatment,IGF-1,MCP-1,luteinizing hormone(LH),follicle stimulating hormone(FSH),LH/FSH and testosterone(T)in two groups were significantly lower than before treatment,and those in the combined group were significantly lower than those in the control group(P<0.05).Superoxide dismutase(SOD)and total antioxidant state(TAS)in the combined group were significantly higher than those in the control group,and serum total oxidation state(TOS)in the combined group was significantly lower than that in the control group(P<0.05).Endometrial thickness was thicker,and ovarian volume in the combined group was significantly smaller than those in the control group(P<0.05).The total effective rate in the combined group was significantly higher than that in the control group(P<0.05).Ovulation rate in the combined group was 80.00%,which was significantly higher than 50.00% in the control group(P<0.05).The pregnancy rate in the combined group was 50.00%,which was significantly higher than 13.33% in the control group(P<0.05).Conclusion Vitamin E combined with metformin has a good effect in infertility patients with PCOS,which can reduce the levels of IGF-1 and MCP-1,improve the levels of sex hormones and oxidative stress,and promote the recovery of patients.

关 键 词：维生素E 二甲双胍 多囊卵巢综合征不孕症 胰岛素样生长因子-1 单核细胞趋化蛋白-1 

分 类 号：R711.75[医药卫生—妇产科学] R446[医药卫生—临床医学]