女性雄激素水平异常升高的病因诊断分析  

The analysis of etiological diagnosis of abnormally elevated androgen levels in women

作　　者：仲思怡 陈捷[1] 顾林[1] 孙艳丽 秦鹏菲 Zhong Siyi;Chen Jie;Gu Lin;Sun Yanli;Qin Pengfei(Department of gynecological endocrinology,affiliated Maternity Hospital of Nanjing Medical University(Nanjing Maternal and child health hospital),Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)妇科内分泌科,江苏南京210004

出　　处：《实用妇科内分泌电子杂志》2022年第6期12-15,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析雄激素水平异常升高的原因,以提高临床对高雄激素血症(HA)的病因诊断。方法回顾性分析9例雄激素异常升高患者的临床资料并复习相关文献。结果9例患者雄激素水平均高于正常值2倍以上,4例为先天性肾上腺皮质增生症(雄激素升高达正常上限的2.9~3.7倍),2例为完全性雄激素不敏感综合征(雄激素达到正常男性水平),3例为分泌雄激素的卵巢肿瘤(雄激素升高达正常上限的4.5~5.5倍)。结论多种疾病会导致女性雄激素水平异常升高,且雄激素升高的水平具有差异性,可协助临床病因诊断。Objective To investigate the causes of Hyperandrogenemia,and try to improve its early diagnosis.Methods The clinical data of 9 patients with abnormal androgen elevation were analyzed retrospectively and the related literatures were reviewed.Results According to the patients*laboratory examinations,the testosterone levels were 2 times higher than normal.4 were congenital adrenal hyperplasia(2.9 to 3.7 times the upper limit of normal),2 were androgen insensitivity syndrome(reach normal male levels),another 3 cases were androgen-secreting tumors of ovary(4.5 to 5.5 times the upper limit of nomial).Conclusion Numerous reasons can lead to hyperandrogenemia.The elevated levels of androgen were different between different diseases,which can assist in clinical diagnosis.

关 键 词：高雄激素血症 先天性肾上腺皮质增生症 雄激素不敏感综合征 分泌雄激素肿瘤 病因诊断 

分 类 号：R711[医药卫生—妇产科学]