新型血管吻合器的结构设计及离体实验研究  

Structural design and ex vitro experimental study for a novel vascular stapler

作　　者：向炀 郭宏波 职康康 王伟 毛琳 宋成利[1] XIANG Yang;GUO Hongbo;ZHI Kangkang;WANG Wei;MAO Lin;SONG Chengli(Shanghai Institute for Minimally Invasive Therapy,School of Health Science and Engineering University of Shanghai for Science and Technology,Shanghai 200093,China;Second Affiliated Hospital of Naval Medical University,Shanghai 200003;PLA Navy Medical Center,Shanghai 200433)

机构地区：[1]上海理工大学健康科学与工程学院,现代微创医疗器械及技术教育部工程研究中心,上海200093 [2]海军军医大学第二附属医院,上海200003 [3]海军特色医学中心,上海200433

出　　处：《生物医学工程研究》2022年第2期172-177,共6页Journal Of Biomedical Engineering Research

基　　金：国家自然科学基金资助项目(51735003);上海理工大学医工交叉项目(10-21-308-415)。

摘　　要：本研究设计了一款新型血管吻合器,通过探究血管与吻合器的相互作用,实现快速高效吻合动静脉血管,为血管端端吻合手术提供可新的方法与器械。通过构建血管吻合器的三维模型,利用3D打印技术快速制作了血管吻合器样机,模拟了不同的单侧施压距离下(0.2、0.3、0.4 mm)血管与吻合环的相互作用。通过体外拉伸实验和渗漏实验,验证血管吻合的有效性。单侧施压距离为0.3 mm时,吻合效果最好,吻合口密封性良好,5 min渗漏量为5.7 mL,其极值水压为(148.25±0.13)mmHg,最大拉伸力为(6.08±1.78)N。本研究的新型血管吻合器可以快速实现血管的端端吻合以及功能重建,通过离体实验初步验证了技术的可行性,后续还需要进一步结构优化设计并进行临床实验。We designed a novel vascular stapler to realize rapid and efficient anastomosis of arteriovenous vessels by exploring the interaction between blood vessels and anastomotic ring,so as to provide new methods and instruments for vascular end-to-end anastomosis.The 3D model of vascular stapler was constructed,and the prototype of vascular stapler was quickly fabricated by 3D printing technology.The interaction between blood vessel and anastomotic ring under different unilateral pressure distances(0.2,0.3,0.4 mm)was simulated;Ex vitro tensile and leak experiments were designed to verify the effectiveness of anastomosis.When the unilateral pressure distance was 0.3 mm,the anastomotic effect was the best,the leakage in 5 min was 5.7 mL,the extreme water pressure was(148.25±0.13)mmHg,and the maximum tensile force was(6.08±1.78)N.The novel vascular stapler can quickly realize the end-to-end anastomosis and functional reconstruction of blood vessels.Its preliminary feasibility is verified by ex vitro experiments,and it is necessary to further optimize the design and carry out clinical experiments.

关 键 词：血管外科 端端吻合 吻合环 有限元分析 生物力学 离体实验 

分 类 号：R318[医药卫生—生物医学工程] R197.39[医药卫生—基础医学]