虫类药物治疗下肢动脉硬化闭塞症的效果及对血管内皮功能的影响  

Clinical Efficacy of Insect Drugs in Treatment of Patients with Arteriosclerosis Obliterans of Lower Extremity and Its Effect on Vascular Endothelial Function

作　　者：张鹤[1] 张涛[2] 张花平 张楠[4] 张凯[1] 李浩杰[1] ZHANG He;ZHANG Tao;ZHANG Hua-ping;ZHANG Nan;ZHANG Kai;LI Hao-jie(Department of Vascular Diseases,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China;Department of Medical Reformation Affairs,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China;Department of Critical Care Medicine,People's Hospital of Shijiazhuang City,Shijiazhuang 050000,China;Department of Vascular Surgery,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]石家庄市中医院脉管科,石家庄050051 [2]石家庄市中医院医改科,石家庄050051 [3]石家庄市人民医院重症医学科,石家庄050000 [4]河北医科大学第二医院血管外科,石家庄050000

出　　处：《临床误诊误治》2022年第6期40-43,共4页Clinical Misdiagnosis & Mistherapy

基　　金：河北省中医药管理局科研计划项目(2021257)。

摘　　要：目的观察虫类药物治疗下肢动脉硬化闭塞症(ASO)临床效果及对血管内皮功能的影响。方法选择2020年11月—2021年8月收治的ASO 90例,按治疗方法分为观察组和对照组,每组45例。2组均给予常规方法治疗,对照组给予口服贝前列素钠片,观察组在对照组基础上给予口服虫类药物。观察2组临床效果,比较2组踝肱指数(ABI)、间歇性跛行距离、血管内皮功能,并分析安全性。结果观察组总有效率高于对照组(P<0.05)。观察组治疗后ABI、一氧化氮高于对照组,间歇性跛行距离长于对照组,单核细胞趋化蛋白-1、内皮素-1、内皮脂酶低于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论虫类药物治疗ASO临床效果好,可改善血管内皮功能,增大间歇性跛行距离,安全可靠。Objective To observe clinical effect of insect drugs in treatment of patients with arteriosclerosis obliterans(ASO)of lower extremity and its effect on vascular endothelial function.Methods A total of 90 patients with ASO of lower extremity admitted between November 2020 and August 2021 were selected and divided into observation group(n=45)and control group(n=45).Both groups were treated with routine methods,and then control group was given Beraprost Na Tablets orally,while observation group was given oral insect drugs on the basis of treatment for control group.In two groups,clinical efficacies were observed,and ankle brachial index(ABI),intermittent claudication distance and vascular endothelial function were compared,and the safety was analyzed.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,in observation group,levels of ABI and nitric oxide were significantly higher,and intermittent claudication distance was longer,while levels of monocyte chemoattractant protein-1,endothelin-1 and endothelial lipase were significantly lower than those in control group(P<0.05).There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05).Conclusion Insect drugs may achieve good clinical efficacy in treatment of patients with ASO of lower extremity,improve vascular endothelial function and increase intermittent claudication distance with good safety.

关 键 词：下肢动脉硬化闭塞症 虫类药物 踝肱指数 间歇性跛行 一氧化氮 单核细胞趋化蛋白-1 内皮素-1 内皮脂酶 

分 类 号：R543.5[医药卫生—心血管疾病]