发作性睡病患者的快速眼球运动密度特征  

Rapid eye movement density characteristics in patients with narcolepsy

作　　者：骆蕾[1] 张杨[1] 陈洁 于周龙 周蓉 范滕滕 孙伟[1] LUO Lei;ZHANG Yang;CHEN Jie;YU Zhoulong;ZHOU Rong;FAN Tengteng;SUN Wei(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC kay Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,China)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083

出　　处：《中国心理卫生杂志》2022年第8期658-662,共5页Chinese Mental Health Journal

基　　金：国家自然科学基金青年科学基金项目(81901345);国家重点研发计划(2018YFC1311604)。

摘　　要：目的:比较快速眼球运动(REM)密度在发作性睡病患者和特发性嗜睡患者中的特点,探讨REM密度作为发作性睡病诊断的生物标志物的可能性。方法:回顾分析以嗜睡(不可抗拒的入睡)为主诉住院且完成整夜多导睡眠监测(nPSG)以及次日多次睡眠潜伏期试验(MSLT)患者40例。以临床诊断为发作性睡病以及MSLT结果平均潜伏期≤8min且出现≥2次睡眠始发REM睡眠现象(SOREMPs)为发作性睡病组(25例),其他为特发性嗜睡组(15例)。比较两组人口学资料,nPSG以及MSLT各项指标结果。结果:与特发性嗜睡组相比,发作性睡病组在MSLT中睡眠潜伏期减少[(9.1±5.9)minvs.(3.8±3.3)min,P<0.001],SOREMPs次数增加[(0.3±0.5)vs.(3.9±1.1),P<0.001],REM密度增加[(3.1±1.2)vs.(4.2±1.6),P<0.05]。结论:与特发性嗜睡患者相比,发作性睡病患者快速眼球运动密度增加,作为发作性睡病辅助诊断的生物标志物可能有意义。Objectives:To compare the characteristics of rapid eye movement(REM) density in patients with narcolepsy and idiopathic hypersomnia, and to explore the possibility of REM density may be used as a biomarker for the diagnosis of narcolepsy.Methods:Nocturnal polysomnography(nPSG),multiple sleep latency test(MSLT) data were compared and analyzed retrospectively among hospitalized patients with idiopathic hypersomnia as chief complaint(n=40).Patients with clinical diagnosis and MSLT ≤ 8 min and SOREMPs ≥ 2 were divided into narcolepsy group(n=25),and others were divided into idiopathic hypersomnia group(n=15).Demographic data, nPSG and MSLT data were compared in narcolepsy and idiopathic hypersomnia patients.Results:The narcolepsy group had significantly shorter sleep latency [(9.1±5.9) min vs.(3.8±3.3) min, P<0.001],more SOREMPs [(0.3±0.5) vs.(3.9±1.1),P<0.001],and more REM density compared with idiopathic hypersomnia group [(3.1±1.2) vs.(4.2±1.6),P<0.05].Conclusions:It suggests that rapid eye movement density is increased in patients with narcolepsy, which may be used as a biomarker of auxiliary diagnosis for narcolepsy.

关 键 词：发作性睡病 特发性嗜睡 REM密度 多导睡眠监测 

分 类 号：R338.63[医药卫生—人体生理学] R749.044[医药卫生—基础医学]