苍附导痰汤联合枸橼酸氯米芬治疗PCOS致不孕症对患者卵巢功能、子宫内膜血流参数及妊娠影响  

Effects of Cangfu daotan decoction combined with clomiphene citrate for treating patients with infertility caused by polycystic ovary syndrome on their ovarian function,endometrial blood flow parameters,and pregnancy

作　　者：张靖 徐茜 ZHANG Jing;XU Qian(Binhai New District Hospital of Traditional Chinese Medicine,Tianjin,300451;Tianjin Medical University General Hospital)

机构地区：[1]天津市滨海新区中医医院,300451 [2]天津医科大学总医院

出　　处：《中国计划生育学杂志》2022年第7期1529-1533,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨苍附导痰汤联合枸橼酸氯米芬治疗多囊卵巢综合征(PCOS)致不孕症疗效及对患者卵巢功能、子宫内膜血流参数及妊娠情况的影响.方法:以本院2018年4月-2020年2月收治的PCOS致不孕症患者108例,随机数字表法分成西药组、中药组、联合组各36例.西药组采用枸橼酸氯米芬,中药组采用苍附导痰汤治疗,联合组采用苍附导痰汤联合枸橼酸氯米芬治疗.治疗3个月经周期后判定疗效,统计卵巢功能指标、子宫内膜血流参数及治疗后1年内妊娠率.结果:联合组总有效率(91.7%)高于西药组(63.9%)和中药组(69.4%),妊娠率(66.7%)高于西药组(38.9%)和中药组(41.7%)(均P<0.05);治疗后3组卵巢体积均缩小,子宫内膜均明显增厚,卵巢基础窦卵泡数量均减少,且联合组上述指标均优于西药组和中药组(均P<0.05);治疗后3组子宫内膜血流搏动指数、阻力指数均降低且联合组低于西药组和中药组(均P<0.05).结论:对PCOS致不孕症患者实施苍附导痰汤联合枸橼酸氯米芬治疗疗效更佳,可更好改善患者卵巢功能及子宫内膜血流参数,有效提高妊娠率.Objective: To investigate the effects of Cangfu daotan decoction combined with clomiphene citrate for treating patients with infertility caused by polycystic ovary syndrome(PCOS) on their ovarian function, endometrial blood flow parameters, and pregnancy situation. Methods: A total of 108 patients with infertility caused by PCOS were selected as the research objects and were divided into three groups(36 cases in each group) by random number table method from April 2018 to February 2020. The patients in group A were given clomiphene citrate, the patients in group B were given Cangfu daotan decoction, and the patients in group C were given Cangfu daotan decoction combined with clomiphene citrate. The efficacy of the patients in the three groups was judged after 3 menstrual cycles of treatment. The ovarian function indexes, endometrial blood flow parameters, and the pregnancy rate within 1 year after treatment of the patients in the three groups were counted. Results: The total effective rate(91.7%) of the patients in group C was significantly higher than that(63.9%) of the patients in group A, and that(69.4%) of the patients in group B. The pregnancy rate(66.7%) of the patients in group C was significantly higher than that(38.9%) of the patients in group A, and that(41.7%) of the patients in group B(all P<0.05). After treatment, the ovarian volume and the number of ovarian basal antral follicles of the patients in the three groups had decreased significantly, and the endometrial thickness of the patients in the three groups had increased significantly, and which of the patients in group C were significantly better than those of the patients in group A and group B(all P<0.05). After treatment, the pulbeat index and resistance index of endometrial blood flow of the patients in the three groups had decreased significantly, and which of the patients in group C were significantly better than those in group A and group B(all P<0.05). Conclusion:Cangfu daotan decoction combined with clomiphene citrate for treating the pat

关 键 词：多囊卵巢综合征不孕症 枸橼酸氯米芬 苍附导痰汤 卵巢功能 子宫内膜血流参数 妊娠 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]