子宫内膜异位症患者血清Gal9、BDNF、PAI-1水平与r-AFS分期关系及预测术后复发  

Relationship between the expression levels of serum galactose lectin 9(GAL9),brain-derived neurotrophic factor(BDNF),and plasminogen activator inhibitor type 1(PAI-1)of patients and their endometriosis r AFS stage and the predictive value of the levels of serum GAL 9,BDNF,and PAI-1 for postoperative recurrence of endometriosis

作　　者：肖慧红 邬瑞霞 冯凯勋 XIAO Huihong;WU Ruixia;FENG Kaixun(Guangzhou Panyu Central Hospital,Guangdong Province,511400)

机构地区：[1]广东省广州市番禺中心医院,511400

出　　处：《中国计划生育学杂志》2022年第7期1651-1654,共4页Chinese Journal of Family Planning

摘　　要：目的:探究血清半乳糖凝集素9(GAL9)、脑源性神经营养因子(BDNF)、纤溶酶原激活物抑制物1型(PAI-1)表达水平与子宫内膜异位症患者r-AFS分期关系及对术后复发预测价值.方法:收集2018年2月-2018年12月本院治疗的104例子宫内膜异位症患者(观察组),产前检查正常孕妇104例(对照组),比较两组及观察组不同分期、不同复发情况孕妇Gal9、BDNF、PAI-1水平差异,以及预测术后异位内膜复发效能.结果:观察组Gal9(637.51±52.34 ng/L)、BDNF(227.58±42.19mg/L)、PAI-1(1357.38±122.92pg/ml)水平均高于对照组(245.83±52.32ng/L、157.86±41.82mg/L、818.26±102.55pg/ml),且Ⅲ-Ⅳ期患者高于Ⅰ-Ⅱ期患者、术后复发患者高于非复发患者(均P<0.05);3指标联合诊断术后复发的曲线下面积(0.892)高于单独指标检测,Gal9、BDNF、PAI-1预测术后复发的临界值分别为811.23ng/L、1801.63pg/ml及269.65mg/L.结论:子宫内膜异位症患者血清Gal9、BDNF、PAI-1水平异常升高,且随r-AFS分期程度及术后复发而升高,Gal9、BDNF、PAI-1联合检测预测术后复发有临床价值.Objective: To study the relationship between the expression levels of galactose lectin 9(GAL9), brain-derived neurotrophic factor(BDNF), plasminogen activator inhibitor type 1(PAI-1) of patients and their r AFS stage of endometriosis(Ems), and to study the predictive value of the levels of serum GAL 9, BDNF, and PAI-1 of the patients for their postoperative recurrence of Ems. Methods: In this prospective study, 104 patients with Ems who were selected in research group, and 104 normal pregnant women who underwent physical examination were selected in control group from February 2018 to December 2018. The levels of Gal 9, BDNF, and PAI-1 of the patients were compared between the two groups, and which of the patients in the research group were compared among the patients with different Ems stage and among the patients with different recurrence of Ems. And the predictive efficacy of the levels of Gal 9, BDNF, and PAI-1 for postoperative recurrence of Ems was analyzed. Results: The levels of Gal 9(637.51±52.34 ng/L), BDNF(227.58±42.19 mg/L), and PAI-1(1357.38±122.92 pg/ml) of the patients in the research group were significantly higher than those(245.83±52.32 ng/L, 157.86±41.82 mg/L, and 818.26±102.55 pg/ml) of the patients in the control group, and which of the patients with Ems stage Ⅲ-Ⅳ in the research group were significantly higher than those of the patients with Ems stageⅠ-Ⅱ, and which of the patients with postoperative recurrence of Ems were significantly higher than those of the patients without postoperative recurrence of Ems(all P<0.05). The area under curve of the combined levels of Gal 9, BDNF, and PAI-1 for diagnosing postoperative Ems recurrence was 0.892, which was significantly higher than that of Gal 9 level, BDNF level, or PAI-1 m level alone. The critical values of Gal 9level,BDNF level,and PAI-1mlevel for predicting postoperative Ems recurrence were 811.23ng/L,1801.63pg/ml,and 269.65mg/L,respectively.Conclusion:The expression levels of serum Gal-9,BDNF,and PAI-1of the patients with Em

关 键 词：子宫内膜异位症 术后复发 半乳糖凝集素 脑源性神经营养因子 纤溶酶原激活物抑制物1型 预测 

分 类 号：R711.71[医药卫生—妇产科学]