阴道环在女性生殖健康方面应用的研究进展  

Research progress of the application of vaginal ring in female reproductive health

作　　者：马彬 董健 杨紫霞 宁美英 MA Bin;DONG Jian;YANG Zixia;NING Meiying(National Research Institute for Family Planning,Beijing,100081;Graduate School of Peking Union Medical College)

机构地区：[1]国家卫生健康委科学技术研究所,北京100081 [2]北京协和医学院研究生院

出　　处：《中国计划生育学杂志》2022年第7期1694-1700,共7页Chinese Journal of Family Planning

基　　金：国家卫生健康委科学技术研究所中央级公益性科研院所基本科研业务费专项资金(2021GJZ07)。

摘　　要：近年来女性生殖健康问题日益突出,如何更好地针对女性疾病达到治疗效果是一个亟待解决的热点问题.阴道环是一种由弹性体制成的环状药物递送系统,能够避免口服制剂的首过效应并实现长期药物缓释作用,以局部给药阴道黏膜收的方式,提高药物吸收速率,降低副作用,增加患者使用依从性,亦不需要专业人士操作.作为一种新型药物递送系统的阴道环已被应用在避孕、激素替代疗法、辅助生殖、抗肿瘤和抗病毒等方面,本文旨在介绍阴道环结构,按疾病区分,归纳总结阴道环在生殖健康方面应用的研究进展,为女性疾病的药物治疗提供新思路.In recent years, the problem of female reproductive health has become increasingly prominent. How to achieve better treatment effect of female diseases is a hot issue to be solved urgently. Vaginal ring is a ring made of elastomers drug delivery system, which can avoid the oral preparation of the first pass effect and can achieve long-term sustained drug release effect. Vaginal ring can improve drug absorption rate and reduce drug side effects in the form of partial dosing vaginal mucosa absorption, and which can increase the female compliance and do not require operation by professional providers. Vaginal ring as a new drug delivery system has been used in contraception, hormone replacement therapy, assisted reproduction, antitumor, and antivirus, etc. This paper aims to introduce the vaginal ring structure and to summarize the research progress of the application of vaginal ring in reproductive health based on different disease, so as to provide new ideas of drug therapy for the female reproductive disease.

关 键 词：药物递送系统 阴道环 首过效应 生殖健康 

分 类 号：R169.1[医药卫生—公共卫生与预防医学]