艾香洗液的工艺改进及质量评定  

Process Improvement and Quality Assessmen of Aixiang Shampoo

作　　者：潘旭 赛纪虎 苗莉 刘军 PAN Xu;SAI Jihu;MIAO Li;LIU Jun(Yinchuan Hospital of Traditional Chinese Medicine,Yinchuan 750001,China)

机构地区：[1]银川市中医医院,宁夏银川750001

出　　处：《中国民族民间医药》2022年第13期43-47,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：艾香洗液的工艺改进及质量评定,宁夏医科大学科学研究基金资助项目(XM2020122)。

摘　　要：目的:优化艾香洗液的处方和制备工艺,并通过初步评价标准、稳定性实验和初步临床试用对其质量进行评价。方法:根据试验筛选较佳处方的样品通过初步质量评价标准、稳定性留样观察和临床试用进行质量对比评定,优选出最佳的制备工艺。结果:优选出艾香洗液的最佳处方量为脂肪醇聚氧乙烯醚硫酸钠(AES)10.8 g、椰油酸单乙醇酰胺(CMEA)1.8 g、茶多酚0.36 g、芳香水15.6 g、CAB-356 g、咪唑啉1.8 g、中药浸膏3 g、油溶性羊毛脂0.6 g、液体石蜡0.3 g、珠光片1.8 g、二(氢化牛脂基)邻苯二甲酸酰胺(TAB-2)0.9 g、薄荷脑0.18 g、乙醇适量、瓜尔胶0.18 g、甘油4.2 g、D-泛醇1 g、聚季铵盐1.2 g、香精适量、氢氧化钠适量、枸橼酸适量。按照该处方制备的洗发剂工艺稳定、成型性较好。结论:确定艾香洗液小试制备工艺,质量稳定、可控,临床应用效果评价较好,可进一步深入研究临床疗效和进行中试规模试验改进。Objective To optimize the prescription and preparation process of Aixiang shampoo,and evaluate its quality through preliminary evaluation criteria,stability experiments and preliminary clinical trials.Methods Samples with better prescriptions were screened according to the test through preliminary quality evaluation criteria,stability retention sample observation and clinical trial for quality comparison and evaluation,and the best preparation process was selected.Result The best prescription quantity of Aixiang shampoo was selected as Fatty alcohol polyoxyethylene ether sodium sulfate(AES)10.8 g,Coconut acid monoethanolamide(CMEA)1.8 g,tea polyphenol 0.36 g,aromatic water 15.6 g,CAB-356 g,imidazoline 1.8 g,traditional Chinese medicine extract 3 g,oil-soluble lanolin 0.6 g,liquid paraffin wax 0.3 g,pearlite 1.8 g,di(hydrogenated tallow)phthalic acid amide(TAB-2)0.9 g,menthol 0.18 g,suitable amount of ethanol,guar gum 0.18 g,glycerin 4.2 g,D-panthenol 1 g,poly quaternary ammonium salt 1.2 g,appropriate amount ofessence,appropriate amount ofsodium hydroxide and citric acid.The shampoo prepared according to this prescription has a stable process and good formability.Conclusion To determine the preparation process of Aixiang shampoo in small trial,the quality is stable and controllable,and the evaluation of clinical application effect is good,which can further study the clinical efficacy and improve the pilot scale test.

关 键 词：艾香汤 洗发剂 制备工艺 质量评定 

分 类 号：R283[医药卫生—中药学]