110例儿童奥密克戎变异株感染恢复期血清IgG 抗体变化  

Change in serum IgG antibody during the recovery stage of Omicron variant infection in children:an analysis of 110 cases

作　　者：张平平[1] 郭艳婷 初玉芹[1] 齐继[1] 连雁[1] 李巍[1] 姚丽娜 ZHANG Ping-Ping;GUO Yan-Ting;CHU Yu-Qin;QI Ji;LIAN Yan;LI Wei;YAO Li-Na(Department of Pediatrics,Tianjin First Central Hospital,Tianjin 300190,China)

机构地区：[1]天津市第一中心医院儿科,天津300190

出　　处：《中国当代儿科杂志》2022年第7期736-741,共6页Chinese Journal of Contemporary Pediatrics

摘　　要：目的探讨儿童严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)奥密克戎(Omicron)变异株感染后恢复期血清抗SARS-CoV-2受体结构域特异性IgG抗体(简称SARS-CoV-2 IgG抗体)水平,了解SARS-CoV-2疫苗(简称新冠疫苗)接种对奥密克戎感染的保护作用。方法回顾性收集2022年1月8日至2月7日天津市确诊奥密克戎变异株感染的新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患儿110例,根据患儿确诊前新冠疫苗接种情况分为4组,加强针接种组(3剂)2例,完全接种组(2剂)90例,不完全接种组(1剂)5例,未接种组13例。比较4组患儿的临床资料和SARS-CoV-2 IgG抗体水平。结果完全接种组确诊年龄大于未接种组(P<0.05),完全接种组的传播途径与未接种组比较差异有统计学意义(P<0.05)。4组患儿性别、临床分型、SARS-CoV-2核酸检测再阳性率比较差异无统计学意义(P>0.05)。97例患儿均接种灭活病毒疫苗,以国药集团中国生物北京生物制品研究所疫苗接种人数最多(85/97,88%)。确诊后1个月加强针接种组、完全接种组SARS-CoV-2 IgG抗体水平高于未接种组(P<0.05);确诊后2个月,完全接种组SARS-CoV-2 IgG抗体水平高于未接种组(P<0.05)。完全接种组患儿确诊后2个月的SARS-CoV-2 IgG抗体水平低于确诊后1个月水平(P<0.05)。结论接种灭活新冠疫苗在奥密克戎流行期对儿童有保护作用,完全接种新冠疫苗的患儿发生奥密克戎感染后保护性抗体SARS-CoV-2 IgG抗体水平在确诊后2个月时有轻度下降。Objective To investigate the serum level of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)-specific RBD IgG antibody(SARS-CoV-2 IgG antibody for short)in children with SARS-CoV-2 Omicron variant infection during the recovery stage,as well as the protective effect of SARS-CoV-2 vaccination against Omicron infection.Methods A retrospective analysis was performed on 110 children who were diagnosed with coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 Omicron variant infection in Tianjin of China from January 8 to February 7,2022.According to the status of vaccination before diagnosis,they were divided into a booster vaccination(3 doses)group with 2 children,a complete vaccination(2 doses)group with 90 children,an incomplete vaccination(1 dose)group with 5 children,and a non-vaccination group with 13 children.The clinical data and IgG level were compared among the 4 groups.Results The complete vaccination group had a significantly higher age than the nonvaccination group at diagnosis(P<0.05),and there was a significant difference in the route of transmission between the two groups(P<0.05).There were no significant differences among the four groups in sex,clinical classification,and repositive rate of SARS-CoV-2 nucleic acid detection(P>0.05).All 97 children were vaccinated with inactivated vaccine,among whom 85 children(88%)were vaccinated with BBIBP-CorV Sinopharm vaccine(Beijing Institute of Biological Products,Beijing,China).At 1 month after diagnosis,the booster vaccination group and the complete vaccination group had a significantly higher level of SARS-CoV-2 IgG antibody than the non-vaccination group(P<0.05),and at 2 months after diagnosis,the complete vaccination group had a significantly higher level of SARS-CoV-2 IgG antibody than the non-vaccination group(P<0.05).For the complete vaccination group,the level of SARS-CoV-2 IgG antibody at 2 months after diagnosis was significantly lower than that at 1 month after diagnosis(P<0.05).Conclusions Vaccination with inactivated SARS-CoV-2 vaccine

关 键 词：新型冠状病毒肺炎 奥密克戎 IGG 疫苗 恢复期 儿童 

分 类 号：R725.6[医药卫生—儿科] R446.6[医药卫生—临床医学]