尼可地尔联合瑞舒伐他汀治疗冠心病不稳定型心绞痛对血脂水平及血管内皮功能的影响  

Effects of nicorandil combined with rosuvastatin on blood lipid level and vascular endothelial function in patients with unstable angina of coronary heart disease

作　　者：贾红梅[1] 王秀丽 李云霞[1] Jia Hongmei;Wang Xiuli;Li Yunxia(Department of Pharmacy,Jinan Second People’s Hospital,Jinan 250000,China;Department of Internal Medicine,Jinan Second People’s Hospital,Jinan 250000,China)

机构地区：[1]济南市第二人民医院药剂科,济南250000 [2]济南市第二人民医院内科,济南250000

出　　处：《中国实用医刊》2022年第8期83-86,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨尼可地尔联合瑞舒伐他汀治疗冠心病不稳定型心绞痛(UA)对血脂水平及血管内皮功能的影响。方法抽取2020年1月至2020年12月济南市第二人民医院收治的冠心病UA患者112例,采用随机数字表法将其分为观察组及对照组,每组56例。对照组给予尼可地尔治疗,观察组给予尼可地尔联合瑞舒伐他汀治疗。比较两组的疗效及治疗前后心绞痛发作情况(发作频率、持续时长、严重程度)、血脂水平、血管内皮功能相关指标。心绞痛严重程度采用西雅图心绞痛量表(SAQ)评价。结果观察组治疗总有效率(96.43%,54/56)高于对照组(83.93%,47/56),P<0.05。治疗后,观察组心绞痛发作频率低于对照组,心绞痛持续时长短于对照组,SAQ评分高于对照组(P<0.05)。治疗后,观察组三酰甘油、总胆固醇、低密度脂蛋白胆固醇、内皮素水平均低于对照组,高密度脂蛋白胆固醇、一氧化氮水平及肱动脉血管舒张功能均高于对照组(P均<0.05)。两组治疗期间均未出现严重不良反应。结论对冠心病UA患者给予尼可地尔联合瑞舒伐他汀治疗,可减轻心绞痛发作程度,降低机体血脂水平,改善血管内皮功能。Objective To investigate the effects of nicorandil combined with rosuvastatin on blood lipid level and vascular endothelial function in patients with unstable angina(UA)of coronary heart disease.Methods One hundred and twelve UA patients with coronary heart disease treated in Jinan Second People’s Hospital from January 2020 to December 2020 were selected.According to random number table method,they were divided into observation group and control group,with 56 cases in each group.The control group was treated with nicorandil,while the observation group was treated with nicorandil combined with rosuvastatin.The curative effect,angina attack(onset frequency,duration and severity of UA),blood lipid level and vascular endothelial function-related indexes before and after treatment were compared between the two groups.The severity of UA was evaluated by Seattle Angina Questionnaire(SAQ).Results The total response rate of treatment in the observation group(96.43%,54/56)was higher than that in the control group(83.93%,47/56),P<0.05.After treatment,onset frequency of UA in the observation group was lower than that in the control group,duration was shorter than that in the control group,and SAQ score was higher than that in the control group(P<0.05).After treatment,the levels of triglyceride,total cholesterol,low-density lipoprotein cholesterol and endothelin in the observation group were lower than those in the control group(all P<0.05),while the levels of high-density lipoprotein cholesterol,nitric oxide and brachial artery flow-mediated dilation were higher than those in the control group(all P<0.05).There was no serious adverse reaction in either group during treatment.Conclusions The application of nicorandil combined with rosuvastatin can alleviate UA onset,reduce levels of blood lipids,and improve vascular endothelial function in UA patients with coronary heart disease.

关 键 词：冠心病 不稳定型心绞痛 尼可地尔 瑞舒伐他汀 血脂水平 血管内皮功能 

分 类 号：R541.4[医药卫生—心血管疾病]