急性心肌梗死患者PCI术中不同给药途径应用替罗非班的效果观察  

Effects of tirofiban by different administration routes on patients with acute myocardial infarction during PCI

作　　者：邹克勇 孙少兵 李大程 Zou Keyong;Sun Shaobing;Li Dacheng(Department of Cardiology III,Nanshi Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]河南省南阳南石医院心内三科,南阳473000

出　　处：《中国实用医刊》2022年第8期87-90,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)中不同给药途径应用替罗非班的效果。方法抽取2017年10月至2020年10月于南阳南石医院接受PCI治疗的109例AMI患者,按照随机数字表法分为对照组(54例)和观察组(55例)。对照组PCI术中静脉注射替罗非班,观察组术中冠状动脉注射替罗非班。比较两组的临床疗效、心功能指标[左室射血分数(LVEF)、心脏指数(CI)]、心室重塑指标[左室舒张末内径(LVD)、左室收缩末内径(LVS)]、肌钙蛋白I(cTnI)、α-羟丁酸脱氢酶(α-HBDH)水平以及术后1年不良心血管事件(MACE)发生率。结果观察组总有效率(94.55%,52/55)高于对照组(81.48%,44/54),P<0.05。两组术前LVEF、CI水平比较差异未见统计学意义(P>0.05);观察组术后LVEF、CI水平高于对照组(P<0.05)。两组术前LVD、LVS水平比较差异未见统计学意义(P>0.05);观察组术后LVD、LVS水平低于对照组(P<0.05)。两组术前cTnI、α-HBDH水平比较差异未见统计学意义(P>0.05);观察组术后cTnI、α-HBDH水平低于对照组(P<0.05)。术后1年,观察组MACE发生率(7.27%,4/55)低于对照组(20.37%,11/54),P<0.05。结论PCI术中替罗非班通过冠状动脉给药治疗AMI,能提高疗效,改善心功能,抑制心室重塑和心肌损伤,预后更好。Objective To investigate the effects of tirofiban by different administration routes on patients with acute myocardial infarction(AMI)during percutaneous coronary intervention(PCI).Methods A total of 109 patients with AMI undergoing PCI in Nanshi Hospital of Nanyang from October 2017 to October 2020 were selected,and they were divided into control group(54 cases)and observation group(55 cases)by random number table method.The control group was given intravenous injection of tirofiban during PCI,and the observation group was given coronary injection of tirofiban.The clinical curative effect,cardiac function indexes including left ventricular ejection fraction(LVEF)and cardiac index(CI),ventricular remodeling indexes including left ventricular end-diastolic diameter(LVD)and left ventricular end-systolic diameter(LVS),cardiac troponin I(cTnI),α-hydroxybutyrate dehydrogenase(α-HBDH),and incidence of major adverse cardiovascular events(MACE)within 1 year were compared between the two groups.Results The total effective rate in the observation group(94.55%,52/55)was higher than that in the control group(81.48%,44/54),P<0.05.There was no significant difference in preoperative levels of LVEF and CI between the two groups(P>0.05);the postoperative levels of LVEF and CI in the observation group were higher than those in the control group(P<0.05).There was no significant difference in preoperative levels of LVD and LVS between the two groups(P>0.05);while the postoperative levels of LVD and LVS in the observation group were lower than those in the control group(P<0.05).There was no significant difference in preoperative levels of cTnI andα-HBDH between the two groups(P>0.05);the postoperative levels of cTnI andα-HBDH in the observation group were lower than those in the control group(P<0.05).The incidence of MACE within 1 year after surgery in the observation group(7.27%,4/55)was lower than that in the control group(20.37%,11/54),P<0.05.Conclusions Coronary injection of tirofiban during PCI can improve curative effects a

关 键 词：经皮冠状动脉成形术 替罗非班 急性心肌梗死 心功能 心室重塑 预后 

分 类 号：R542.22[医药卫生—心血管疾病]