Associations of Gestational Diabetes Mellitus and Excessive Gestational Weight Gain with Offspring Obesity Risk  

作　　者：Qi LIU Wei XIA Xin XIONG Ju-xiao LI Ying LI Shun-qing XU Yuan-yuan LI 

机构地区：[1]Key Laboratory of Environment and Health,Ministry of Education and Ministry of Environmental Protection,and State Key Laboratory of Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Current Medical Science》2022年第3期520-529,共10页当代医学科学（英文）

基　　金：Fundamental Research Funds for the Central Universities(No.2015ZDTD047,No.2016YXZD043 and No.2018KFYXMPT00);Program for HUST Academic Frontier Youth Team(No.2018QYTD12);Grants from the National Key Research and Development Plan(No.2016YFC0206203).

摘　　要：Objective Gestational diabetes mellitus(GDM)and gestational weight gain(GWG)are important risk factors that are known to affect offspring growth,but these outcomes are inconsistent and it remains unknown if both risk factors have a synergetic effect on early childhood growth.The present study aimed to conduct offspring body mass index-for-age Z-scores(BMIZ)trajectories and to evaluate the independent and interactive effect of the status of GDM and excessive GWG on the risks of overweight/obesity from birth to 24 months of age.Methods A total of 7949 mother-child pairs were enrolled in this study.The weight and length of children were measured at birth,6,12,and 24 months of age to calculate BMIZ.Results The status of GDM was positively associated with offspring BMIZ and risk of macrosomia at birth but was not associated with offspring BMIZ or the risks of overweight/obesity at 6,12,and 24 months of age.In contrast,excessive GWG was positively linked to offspring BMIZ,the stable high BMIZ trajectory pattern,and risks of overweight/obesity in the first 24 months of age.These two risk factors also had a significant synergistic effect on macrosomia at birth,but the interactive effect was only significant in boys during the follow-up years in the sex-stratified analyses.Conclusion The maternal GWG was a more pronounced predictor than GDM with relation to BMIZ and risk of overweight/obesity in early childhood.The interactive effect between these risk factors on offspring overweight/obesity may vary by sex.

关 键 词：gestational diabetes mellitus gestational weight gain offspring growth childhood overweight/obesity 

分 类 号：R71[医药卫生—妇产科学]