Nogo-B受体的生物学功能  

Biological function of Nogo-B receptor

作　　者：朱莹 张利群 李建东 ZHU Ying;ZHANG Li-Qun;LI Jian-Dong(Department of Respiratory and Critical Care Medicine,Eighth Medical Center of Chinese PLA General Hospital,Beijing 100091,China)

机构地区：[1]中国人民解放军总医院第八医学中心,呼吸与危重症医学部,北京100091

出　　处：《生理学报》2022年第2期301-308,共8页Acta Physiologica Sinica

基　　金：supported by the National Natural Science Foundation of China (No.81700069);the Clinical Research Project of Beijing Municipal Science and Technology Commission,China (No.Z181100001718024);major project of Eighth Medical Center of Chinese PLA General Hospital (No.2021ZD005)。

摘　　要：Nogo-B受体(Nogo-B receptor, NgBR)是网状蛋白家族4成员Nogo-B的受体,广泛分布于机体的多种组织和器官,并定位于细胞膜及内质网。NgBR参与了体内多种生理和病理生理过程,如多萜醇合成、脂肪代谢、胆固醇转运,以及胰岛素抵抗、血管重塑和生成、肿瘤形成和神经系统疾病等。本文拟对近年来关于NgBR的结构与功能做一简要综述。对NgBR的结构及功能的进一步探究,将有助于深入了解其参与各种疾病的作用机制,为疾病的防治提供可能的临床策略。Nogo-B receptor(NgBR) is a specific receptor of Nogo-B, a member of reticulon 4 protein family. It is widely expressed in many tissues and mainly located in cell membrane and endoplasmic reticulum. Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking,insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. Further studies on the molecular characteristics and biological function of NgBR might be of great significance to understand its role in diverse diseases and provide possible clinical strategies for the treatment of diseases.

关 键 词：Nogo-B受体 Nogo-B NUS1 胆固醇转运 肿瘤形成 

分 类 号：R341[医药卫生—基础医学]