I-TAC、IL-1家族第7因子及IGFBP-5在结核病诊断中的应用比较  

Comparison of the application of I-TAC,IL-1 family factor 7 and IGFBP-5 in the diagnosis of tuberculosis

作　　者：陈玉芊 王世军 王欣[3] 徐修礼 CHEN Yuqian;WANG Shijun;WANG Xin;XU Xiuli(Xi′an Regional Medical Laboratory Center,Xi′an,Shaanxi 710116,China;Department of Clinical Laboratory,Lanzhou Pulmonary Hospital,Lanzhou,Gansu 730046,China;Inspection Center,Gansu Provincial People′s Hospital,Lanzhou,Gansu 730013,China)

机构地区：[1]西安区域医学检验中心,陕西西安710116 [2]兰州市肺科医院检验科,甘肃兰州730046 [3]甘肃省人民医院检验中心,甘肃兰州730013

出　　处：《检验医学与临床》2022年第14期1958-1960,1965,共4页Laboratory Medicine and Clinic

摘　　要：目的分析痰液干扰素诱导的T细胞α亚族趋化因子(I-TAC)、白细胞介素(IL)-1家族第7因子、胰岛素样生长因子结合蛋白5(IGFBP-5)在结核病诊断中的应用价值。方法选取兰州市肺科医院2019年6月至2020年6月收治的80例结核病患者为观察组,同期80例非结核病患者为对照组,比较两组患者痰液中的IL-1家族第7因子、I-TAC、IGFBP-5水平及阳性率,并对比3项指标对结核病的诊断效能。结果观察组的I-TAC、IL-1家族第7因子、IGFBP-5水平及阳性率均明显高于对照组,差异有统计学意义(P<0.05);I-TAC诊断结核病的灵敏度、特异度、阳性预测值、阴性预测值均高于IL-1家族第7因子和IGFBP-5,差异有统计学意义(P<0.05)。结论在结核病诊断中I-TAC的诊断效能高,可作为优选标志物加以使用。Objective To analyze the application value of interferon-induced T cellαchemokine(I-TAC),interleukin(IL)-1 family factor 7 and insulin-like growth factor binding protein 5(IGFBP-5)induced by sputum interferon in the diagnosis of tuberculosis.Methods A total of 80 tuberculosis patients who received treatment from June 2019 to June 2020 in Lanzhou Pulmonary Hospital were selected as the observation group,and 80 non-tuberculous patients during the same period were selected as the control group.The levels and positive rates of IL-1 family factor 7,I-TAC,IGFBP-5 in the sputum of the two groups were compared,then compared the diagnostic efficiency of the three indicators in diagnosing tuberculosis.Results The levels and positive rates of IL-1 family factor 7,I-TAC,IGFBP-5 in the sputum of observation group were significantly higher than those of control group,the differences were statistically significant(P<0.05).The sensitivity,specificity,positive predictive value and negative predictive value of I-TAC in diagnosing tuberculosis were higher than those of IL-1 family factor 7 and IGFBP-5,the differences were statistically significant(P<0.05).Conclusion I-TAC has high diagnostic efficiency in the diagnosis of tuberculosis and could be used as a preferred marker.

关 键 词：结核病 干扰素诱导的T细胞α亚族趋化因子 白细胞介素-1家族第7因子 胰岛素样生长因子结合蛋白5 

分 类 号：R446.9[医药卫生—诊断学]