轻型地中海贫血对辅助生殖技术妊娠结局的影响  

Effects of mild thalassemia on pregnancy outcome of assisted reproductive technology

作　　者：林慧 许承明 文平 胡素熔 段金良 LIN Hui;XU Cheng-ming;WEN Ping;HU Su-rong;DUAN Jin-liang(Reproductive Medicine Center,The 924 th Hospital of PLA Joint Logistic Support Force,Guilin 541002)

机构地区：[1]中国人民解放军联勤保障部队第九二四医院生殖中心,桂林541002

出　　处：《生殖医学杂志》2022年第7期926-930,共5页Journal of Reproductive Medicine

基　　金：军队计生专项研究任务计划(17JS008);广西卫健委计划课题(Z20190279)。

摘　　要：目的探讨轻型地中海贫血(简称地贫)对辅助生殖技术(ART)妊娠结局的影响。方法回顾性分析2018年1月1日至12月31日在本生殖中心经地贫基因检测确诊为轻型地贫,且首次取卵的174对夫妇的临床资料。按照男、女方地贫基因检测结果分为:女性轻型地贫组(男方地贫基因正常)88例,共88个取卵周期、111个移植周期;男性轻型地贫组(女方地贫基因正常)86例,共86个取卵周期、115个移植周期。选择同期来院治疗、夫妻双方地贫基因检测正常的100例不孕症妇女为非地贫组(100个取卵周期,126个移植周期)。比较3组患者的一般资料、胚胎发育情况及妊娠结局。结果3组患者的一般资料及D3胚胎数、D3优质胚胎率、囊胚形成率、优质囊胚率等胚胎发育情况比较均无显著性差异(P>0.05)。3组患者的临床妊娠率、多胎妊娠率、早产率、活产率、异位妊娠率等亦无显著性差异(P>0.05),女性轻型组的流产率和胎儿畸形率有高于其他两组的趋势,但尚无显著性差异(P>0.05)。结论男方或女方轻型地贫均不会明显影响ART的妊娠结局,但是女方为轻型地贫时可能有增加不良妊娠结局的趋势。Objective:To investigate the effect of mild thalassemia on pregnancy outcome of assisted reproductive technology.Methods:The clinical data of 174 couples who were diagnosed as mild thalassemia by gene screening and they underwent oocytes retrieved for the first time in our reproductive center from January 1 to December 31,2018 were analyzed retrospectively.According to the results of male and female thalassemia gene test,the couples were divided into two groups:female mild thalassemia group(male thalassemia gene is normal)(88 couples,88 oocyte retrieved cycles and 111 transfer cycles)and male mild thalassemia group(female thalassemia gene was normal)(86 couples,86 oocyte retrieved cycles and 115 transfer cycles).Hundred infertile couples with normal thalassemia gene who came to the hospital for ART treatment in the same period were selected as the non-thalassemia group(100 oocyte retrieved cycles and 126 transfer cycles).The general information,embryonic development and pregnancy outcome were compared among the three groups.Results:There were no significant differences in the numbers of Day 3 embryos,Day 3 good-quality embryos,blastocyst formation rate,high-quality blastocyst rate etc.(P>0.05).There were also no significant differences in clinical pregnancy rate,multiple pregnancy rate,premature delivery rate,live birth rate,ectopic pregnancy rate,etc.among these 3 groups(P>0.05),but the abortion rate and fetal malformation rate in women mild thalassemia group were slightly higher than in the other two groups.Conclusions:Neither male nor female mild thalassemia significantly affected the pregnancy outcome of ART.However,women with mild thalassemia may have a tendency to increase adverse pregnancy outcomes.

关 键 词：轻型地中海贫血 辅助生殖技术 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学] R556[医药卫生—临床医学]