影响夫精人工授精妊娠结局相关因素分析  

Analysis of related factors affecting pregnancy outcome of intrauterine insemination with husband semen

作　　者：马晓娟 岳小妹 乔婷 孟晓楠 Ma XiaoJuan;Yue XiaoMei;Qiao Ting(Pingdingshan Maternal and Child Health Hospital in Hennan Province,Center for Reproductive,Pingdingshan 467000,China)

机构地区：[1]河南省平顶山市妇幼保健院生殖中心,河南平顶山467000

出　　处：《华北理工大学学报（医学版）》2022年第4期260-265,共6页Journal of North China University of Science and Technology：Health Sciences Edition

摘　　要：目的探讨影响夫精人工授精(intrauterine insemination with husband semen,AIH)妊娠结局的因素。方法收集2015年1月~2019年12月在平顶山市妇幼保健院生殖医学中心接受AIH助孕治疗的患者732例共1303周期临床资料,分别比较不同方案组间夫妻年龄、不孕年限、女方体质量指数(BMI)、基础卵泡刺激素(FSH)、基础黄体生成素(LH)、基础雌二醇(E_(2))、生化妊娠率、临床妊娠率、流产率、双胎妊娠率及妊娠晚期结局(产妇分娩孕周、新生儿性别、新生儿出生体质量、新生儿身长、低体质量儿、早产率、巨大儿率、剖宫产率、妊娠期糖尿病、妊娠期高血压疾病、产后出血及活产率);同时比较夫妇年龄、女方BMI、人工授精周期数、人工授精时机、注入精子量对妊娠结局的影响。结果自然周期组和促排周期组间夫妇年龄、FSH、E_(2)、异位妊娠率、流产率、双胎妊娠率比较差异均无统计学意义(P>0.05);促排周期组基础LH、女方BMI、临床妊娠率、活产率高于自然周期组,差异有统计学意义(P<0.05);女方年龄<35岁组临床妊娠率、活产率高于≥35岁组,差异有统计学意义(P<0.05)。男方年龄<35岁组妊娠率高于≥35岁组,差异有统计学意义(P<0.05)。结论夫妇年龄、助孕方案是影响AIH妊娠的主要因素;女方BMI、人工授精时机、注入精子量对AIH成功率无显著影响。3个周期AIH仍未孕者,建议改行体外受精-胚胎移植助孕技术。Objective To investigate irelated factors affecting pregnancy outcome of intrauterine insemination with husband semen.Methods The clinical data of 1303 cycles of 732 patients who received AIH assisted pregnancy treatment were retrospective analyzed in our Hospital of Pingdingshan Maternal and Child Health Hospital Center of Reproductive from January 2015 to December 2019.Including couples age,infertility duration,female body mass index,basic of FSH,LH,E_(2) levels,treatment regimens,the number of cycles,timing of insemination,pregnancy,miscarriage were compare of related factor on the pregnancy outcome of artificialin semination with husbands sperm.Results There was no obvious difference incouples age,basic of FSH,E_(2) levels,abortion rate,ectopic pregnancy rate,twin pregnancy rate between nature cycle group and ovulation cycle group(P>0.05).Clinical pregnancy rate,iuteinizing hormone,BMI were higher in ovulation cycle group than in nature cycle group(P<0.05).Clinical pregnancy rates of patient less than 35 years old are higher than more than 35 years(P<0.05).Conclusion Clinical pregnancy rate were higher in ovulation cycle group than in nature cycle group;couples age and treatment regimenshas are significant effect on the outcome of artificialin semination with Husbands sperm,but there is not influence for man age,body mass index,the number of cycles,timing of insemination for artificialin semination with Husbands sperm in pregnancy outcome.IVF treatment should be considered for those women who did not get pregnancy after 3 AIH treatment cycles.

关 键 词：夫精人工授精 临床妊娠率 人工授精时机 自然周期 促排卵周期 

分 类 号：R711.71[医药卫生—妇产科学]