老年2型糖尿病患者合并肌少症发生的影响因素  

Influential Factors of Sarcopenia in Older Patients with Type 2 Diabetes Mellitus

作　　者：田甜[1] 张山山 姚霞[1] 井源[1] 刘焕乐[1] 崔凯[1] Tian Tian;Zhang Shanshan;Yao Xia;Jing Yuan;Liu Huanle;Cui Kai(Department of Geriatrics,Shengli Oilfield Central Hospital,Dongying 257000)

机构地区：[1]山东省东营市胜利油田中心医院老年病科,东营257000

出　　处：《国际老年医学杂志》2022年第4期438-441,共4页International Journal of Geriatrics

基　　金：山东省优秀中青年科学家科研奖励基金(BS2017SW298)。

摘　　要：目的调查老年2型糖尿病患者合并肌少症发生的影响因素。方法选取2016年12月~2019年12月间收治的450例老年2型糖尿病患者进行回顾性分析,根据患者是否合并肌少症分为单纯糖尿病组(408例)和合并肌少症组(42例)。对比两组一般资料及实验室检查结果,分析老年2型糖尿病患者合并肌少症发生的影响因素。结果单纯糖尿病组和合并肌少症组的性别、年龄、吸烟、阻塞性睡眠呼吸暂停综合征(OSA)、体质指数、四肢骨骼肌肌肉质量指数、空腹血糖、糖化血红蛋白(HbA1c)、握力、步速比较,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果提示,男性(OR=1.761,95%CI=1.315~2.254)、年龄(OR=2.394,95%CI=1.673~3.066)、OSA(OR=3.028,95%CI=2.038~4.113)、HbA1c(OR=5.217,95%CI=2.514~10.093)是老年2型糖尿病患者发生肌少症的独立危险因素(P<0.05)。结论老年2型糖尿病易合并肌少症,OSA、高龄、男性和血糖控制不佳可以增加肌少症患病风险。Objective To investigate the influential factors of sarcopenia in older patients with type 2 diabetes mellitus(T2 DM).Methods A retrospective analysis was conducted in 450 older patients with T2 DM treated in the hospital from December 2016 to December 2019.According to the occurrence of sarcopenia,the patients were divided into the simple diabetes group and diabetes with sarcopenia group.The general data and laboratory test results in the two groups were compared.The influential factors of sarcopenia in older T2 DM patients were analyzed.Results There were statistically significant differences in gender,age,smoking,obstructive sleep apnea(OSA),body mass index(BMI),appendicular skeletal muscle mass index(ASMI),fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1 c),grip strength and pace between the two groups(P<0.05).Multivariate logistic regression analysis showed that male(OR=1.761,95%CI=1.315-2.254),age(OR=2.394,95%CI=1.673-3.066),OSA(OR=3.028,95%CI=2.038-4.113)and HbA1 c(OR=5.217,95%CI=2.514-10.093)were independent risk factors for sarcopenia in older patients with T2 DM.Conclusion Older patients with T2 DM are prone to sarcopenia.OSA,advanced age,male,and poor blood glucose control may increase the risk of sarcopenia.

关 键 词：2型糖尿病 肌少症 性别 年龄 阻塞性睡眠呼吸暂停 糖化血红蛋白 

分 类 号：R587.2[医药卫生—内分泌] R685[医药卫生—内科学]