细胞自噬与常见老年病的关联性研究进展  

Study Progress on the Relationship Between Autophagy and Common Senile Diseases

作　　者：丁宇[1] 王彦丰 李小溪[1] 艾学龙 王媛媛[1] 王彦斌 左夏林 李霞 姚翔 丁克祥 Ding Yu;Wang Yanfeng;Li Xiaoxi;Ai Xuelong;Wang Yuanyuan;Wang Yanbin;Zuo Xialin;Li Xia;Yao Xiang;Ding Kexiang(Nanfang Hospital,Southern Medical University,Guangzhou 510515;Guangzhou Haomei Biotechnology Co.LTD.,Guangzhou 510515;School of Public Health,Southern Medical University,Guangzhou 510515)

机构地区：[1]南方医科大学附属南方医院,广州510515 [2]广州好美生物科技有限公司,广州510000 [3]南方医科大学公共卫生学院,广州510515

出　　处：《国际老年医学杂志》2022年第4期468-471,共4页International Journal of Geriatrics

基　　金：国家自然科学基金项目(81501952)。

摘　　要：自噬是机体利用自身溶酶体对细胞内受损细胞器、衰老及变性的大分子物质消化和降解,并合理利用的有效代谢途径。也是细胞维持自身正常形态结构和代谢功能的重要生物学机制之一。人体衰老表现为自噬效应降低或不足,而自噬效应降低或不足又可导致老年病患者出现细胞自噬功能异常。自噬失衡与衰老和老年病的发生、发展密切相关。采用适度的细胞自噬干预手段,有利于延缓机体衰老的进展,对防治老年病具有积极意义。Autophagy is an effective and reasonable metabolic pathway to use lysosome to digest damaged organelles,aging and denaturation of macromolecul within the cell.It is also an important biological mechanism for cells to maintain their normal structure and metabolic function stability.Aging is characterized by reduced or insufficient autophagy effect,which can lead to abnormal autophagy in patients with senile diseases.Autophagy imbalance is closely related to human aging and the occurrence and development of some senile diseases.The intervention of autophagy might slow down then aging process and progress,and has positive significance in the prevention and control of the senile diseases.

关 键 词：人体衰老 老年病 自噬 相关性 

分 类 号：R592[医药卫生—老年医学]