短期胰岛素强化与口服三联方案治疗T2DM患者对血糖、胰岛素抵抗及脂肪细胞因子的影响  

Effects of Short-Term Insulin Intensive Therapy and Oral Triple Regimen on Blood Glucose,Insulin Resistance and Adipocytokines in Patients with Type 2 Diabetes Mellitus

作　　者：冯赓 马龙飞[1] 张惠莹 FENG Geng;MA Long-fei;ZHANG Hui-ying(Department of Endocrinology,Jiaozuo People's Hospital,Jiaozuo,Henan,454002,China;Department of Endoscopy,Jiaozuo People's Hospital,Jiaozuo,Henan,454002,China)

机构地区：[1]河南省焦作市人民医院内分泌二区,河南焦作454002 [2]河南省焦作市人民医院内窥镜室,河南焦作454002

出　　处：《中国血液流变学杂志》2022年第1期76-79,145,共5页Chinese Journal of Hemorheology

摘　　要：目的探讨短期胰岛素强化与口服三联方案治疗2型糖尿病(T2DM)患者对血糖、胰岛素抵抗及脂肪细胞因子的影响。方法选取2016年1月—2018年6月收治的146例T2DM患者,按随机数表法分为短期胰岛素强化组(Y组)和口服三联方案组(S组)各73例。观察两组治疗前后血糖、胰岛素相关指标、脂肪细胞因子和低血糖发生率、血糖达标时间。结果两组治疗前FPG、2hPG、HbA1c比较差异无统计学意义(P>0.05),两组治疗后FPG、2hPG、HbA1c较治疗前明显下降(P<0.05),与Y组治疗后比较,S组血糖下降更显著(P<0.05)。两组治疗前胰岛素相关指标比较差异无统计学意义(P>0.05),两组治疗后HOMA-β高于治疗前,HOMA-IR低于治疗前(P<0.05),与Y组治疗后比较,S组HOMA-β明显上升,HOMA-IR明显降低(P<0.05)。两组治疗前脂肪细胞因子比较差异无统计学意义(P>0.05),两组治疗后Leptin、TNF-α、FFA低于治疗前,ADP高于治疗前(P<0.05)。与Y组治疗后比较,S组ADP升高,Lep-tin、TNF-α、FFA降低更显著(P<0.05)。Y组低血糖发生率(24.6%)高于S组(6.8%)(P<0.05),两组血糖达标时间差异无统计学意义(P>0.05)。结论短期胰岛素强化与口服三联方案均可治疗T2DM,与短期胰岛素强化治疗方案相比,口服三联方案在改善血糖变化、胰岛素抵抗及脂肪细胞因子等疗效更显著。Objective To investigate the effects of short-term insulin intensive therapy and oral triple therapy on blood glucose,insulin resistance and adipocytokines in patients with type 2 diabetes mellitus(T2DM).Methods A total of 146 patients with T2DM were selected and divided into short-term insulin intensive group(Y group)and oral triple regimen group(S group)according to the random number table method,73 cases in each.The blood glucose,insulin-related indexes,adipocytokines,incidence of hypoglycemia and the time of reaching the standard of blood glucose were observed before and after treatment in the two groups.Results There was no significant difference in FPG,2hPG and HbA1c before treatment between two groups(P>0.05).After treatment,FPG,2hPG and HbA1c in the two groups were significantly lower than those before treatment(P<0.05).Compared with group Y after treatment,FPG,2hPG and HbA1c in group S decreased significantly(P<0.05).There was no significant difference in insulin-related indexes before treatment between two groups(P>0.05).After treatment in the two groups,HOMA-βwas higher than that before treatment,and HOMA-IR was lower than that before treatment(P<0.05).Compared with group Y after treatment,HOMA-βin group S increased significantly and HOMA-IR decreased significantly(P<0.05).There was no significant difference in adipocytokines before treatment between two groups(P>0.05).After treatment in the two groups,Lep-tin,TNF-αand FFA were lower than those before treatment,and ADP was higher than that before treatment(P<0.05).Compared with group Y after treatment,ADP in group S increased significantly,Lep-tin,TNF-αand FFA decreased significantly(P<0.05).The incidence of hypoglycemia in group Y(24.6%)was higher than that in group S(6.8%)(P<0.05),and there was no significant difference in the time of reaching the standard of blood glucose between the two groups(P>0.05).Conclusion Both short-term insulin intensive therapy and oral triple therapy can treat T2DM.Oral triple therapy is better than short-term insulin

关 键 词：胰岛素 胰岛素抵抗 2型糖尿病 三联方案 

分 类 号：R587.1[医药卫生—内分泌]