新型杀虫剂氟啶脲的合成工艺改进  

Improvement of Synthesis Process of Novel Insecticide Fluoxazuron

作　　者：邵倩 秦岭 李强 王纯 付达权 刘殿卿 罗艺 何东贤 SHAO Qian;QIN Ling;LI Qiang;WANG Chun;FU Da-quan;LIU Dian-qing;LUO Yi;HE Dong-xian(Chongqing Medical and Pharmaceutical College,Chongqing 400000;Chongqing Pesticide Chemical(Group)Co.,Ltd.,Chongqing 400000;Chongqing University of Technology,Chongqing 400000,China)

机构地区：[1]重庆医药高等专科学校,重庆400000 [2]重庆农药化工(集团)有限公司,重庆400000 [3]重庆理工大学,重庆400000

出　　处：《广州化工》2022年第13期51-54,共4页GuangZhou Chemical Industry

基　　金：重庆市技术创新与应用发展专项(cstc2020jscx-msxmX0022)。

摘　　要：氟啶脲是苯甲酰脲类生物农药中一种重要的高效低毒杀虫剂。本研究以2,6-二氯苯酚为原料,先经过硝化得到2,6-二氯-4-硝基苯酚,再经过还原得到2,6-二氯-4-氨基苯酚。2,6-二氯-4-氨基苯酚与2,3-二氯-5-三氟甲基吡啶缩合得到醚化物。所得醚化物与2,6-二氟苯甲酰异氰酸酯进行缩合得到氟啶脲成品,五步总收率85%。此工艺在降低生产成本的同时,提高了氟啶脲收率和成品品质,更有利于环境保护,也更适合于工业化大生产。Fluoxazuron is an important high-efficiency and low-toxicity pesticide among benzoylurea biopesticides.2,6-dichlorophenol was used as raw material, 2,6-dichloro-4-nitrophenol was obtained by nitration, and then 2,6-dichloro-4-aminophenol was obtained by reduction.2,6-dichloro-4-aminophenol was condensed with 2,3-dichloro-5-trifluoromethylpyridine to obtain etherate.The obtained etherate was condensed with 2,6-difluorobenzoyl isocyanate to obtain the finished product of fluorazuron, and the total yield of five steps was 85%.While reducing the production cost, the process improved the yield of fluoride and the quality of the finished product, was more conducive to environmental protection, and was more suitable for industrialized large-scale production.

关 键 词：氟啶脲 苯甲酰脲 缩合 杀虫剂 

分 类 号：TQ450.6[化学工程—农药化工]