功能磁共振成像在青少年肌阵挛性癫痫中的脑网络及内表型研究进展  

Advances of brain network and endophenotypes in fMRI in juvenile myoclonic epilepsy

作　　者：张馨 任洁钏[2] 暴军香 ZHANG Xin;REN Jiechuan;BAO Junxiang(Department of Aerospace Hygiene,Air Force Medical University,Xi'an 710032,China;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]空军军医大学航空航天医学系,西安710032 [2]首都医科大学附属北京天坛医院神经病学中心,北京100070

出　　处：《磁共振成像》2022年第7期143-146,155,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81601126)。

摘　　要：青少年肌阵挛性癫痫(juvenile myoclonic epilepsy,JME)是一种从青春期开始的终生疾病。JME患者的认知水平下降,异常的网络连接被认为是引起认知功能障碍的原因。基于功能磁共振成像(functional magnetic resonance imaging,fMRI)的研究对揭示JME患者脑功能网络异常及认知功能障碍已取得显著成果,在阐明JME生理病理方面具有重大潜力。功能网络连接研究阐明了JME患者脑网络的改变并帮助理解JME的神经机制。非传统脑电-功能磁共振成像(electroencephalography-functional magnetic resonance imaging,EEG-fMRI)联合研究EEG的动态网络相关联的血氧水平依赖(blood oxygen level dependent,BOLD)活动,从新的角度揭示JME神经机制。JME内表型的fMRI研究可帮助提供临床特征和潜在遗传特征之间的联系。本文将对fMRI在JME脑网络、EEG的动态网络相关联的BOLD活动及内表型研究进展进行综述。Juvenile myoclonic epilepsy(JME)is a lifelong disorder that begins in adolescence.Cognitive decline and abnormal network connectivity are thought to be responsible for cognitive dysfunction in JME patients.Functional magnetic resonance imaging(fMRI)studies have achieved remarkable results in revealing abnormalities of brain functional network and cognitive dysfunction in JME patients,and have significant potentialities to elucidate the physiopathology of JME.Functional network connectivity studies elucidate alterations in brain network of JME patients and help understand the neural mechanisms of JME.Non-traditional electroencephalography-functional magnetic resonance imaging(EEG-fMRI)studies blood oxygen level dependent(BOLD)activities associated dynamic network of EEG,sheding new light on the neural mechanisms of JME.Endophenotypes studies of JME in fMRI help provide a link between clinical features and underlying genetic characteristics.In this article,we will review the advance of brain network,BOLD activities associated dynamic network of EEG and endophenotypes of JME in fMRI.

关 键 词：功能磁共振成像 青少年肌阵挛性癫痫 脑功能网络 内表型 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.1[医药卫生—诊断学]