Low-dose chloroquine treatment extends the lifespan of aged rats  

作　　者：Wei Li Zhiran Zou Yusheng Cai Kuan Yang Si Wang Zunpeng Liu Lingling Geng Qun Chu Zhejun Ji Piu Chan Guang-Hui Liu Moshi Song Jing Qu Weiqi Zhang 

机构地区：[1]Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital Capital Medical University,Beijing 100053,China [2]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [3]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [4]CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China [5]China National Center for Bioinformation,Beijing 100101,China [6]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [7]University of Chinese Academy of Sciences,Beijing 100049,China [8]Aging Translational Medicine Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [9]Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China [10]Sino-Danish College,University of Chinese Academy of Sciences,Beijing 101408,China [11]Sino-Danish Center for Education and Research,Beijing 101408,China [12]Chongqing Renji Hospital,University of Chinese Academy of Sciences,Chongqing 400062,China

出　　处：《Protein & Cell》2022年第6期454-461,共8页蛋白质与细胞（英文版）

基　　金：the National Key Research and Development Program of China(2018YFC2000100);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16000000);the Program of Beijing Municipal Science and Technology Commission(Z191100001519005);the National Natural Science Foundation of China(Grant Nos.81921006,8162500991749202,81861168034,91949209,92049304,81822018,81870228,81922027,82071588,92049116,31801010,81901433,82125011,82122024,92149301,92168201);the National Key Research and Development Program of China(2020YFA0804000,2020YFA0112200,2017YFA0103304,2017YFA0102802,2018YFA0107203,2020YFA0113400);the Program of the Beijing Natural Science Foundation(Z190019,JQ20031);the Key Research Program of the Chinese Academy of Sciences(KFZDSW-221);K.C.Wong Education Foundation(GJTD-2019-06,GJTD-2019-08);Beijing Hospitals Authority Youth Programme(QML20200802);Youth Innovation Promotion Association of CAS(E1CAZW0401,2021078);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-JKCS-011);the State Key Laboratory of Stem Cell and Reproductive Biology,the State Key Laboratory of Membrane Biology,the 14th Five-year Network Security and Informatization Plan of Chinese Academy of Sciences(WX145XQ07-18);the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0301);the Milky Way Research Foundation(MWRF),Young Elite Scientists Sponsorship Program by CAST(NO.YESS20200012);CAS Project for Young Scientists in Basic Research(YSBR-012)and the Tencent Foundation.

摘　　要：Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020).However,the safety and efficacy of its applications are still under extensive debate(Solomon and Lee,2009).Here,we discovered that low-dose CQ has a geroprotective effect on physiologically aged rats.Low-dose CQ prolonged lifespan,repressed systemic inflammation,and inhibited fibrosis across multiple tissue types in aged rats.Furthermore,we constructed transcriptomic maps for 6 tissues(kidney,small intestine,liver,heart,lung,and aorta)upon CQ treatment,thus revealing the effects of CQ at a systemic level.CQ treatment mitigated age-related molecular changes and repressed genes linked to fibrosis and the inflammatory response.Altogether,our data provide a valuable resource for investigating the impact of CQ on multiple aged tissues,which may facilitate the development of clinical applications that mitigate age-related changes in the elderly.

关 键 词：protective inhibited INTESTINE 

分 类 号：R339.3[医药卫生—人体生理学]