丙型肝炎病毒抗体阳性患者HCV-RNA与ALT结果分析  

An Analysis of Hepatitis C RNA and Alanine Aminotransferase in Patients with Positive Hepatitis C Antibody

作　　者：袁梁[1] 张明新[1] 张韶娅 张晓红[1] 刘向祎[1] YUAN Liang;ZHANG Mingxin;ZHANG Shaoya;ZHANG Xiaohong;LIU Xiangyi(Beijing Tongren Hospital,CMU,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京100730

出　　处：《标记免疫分析与临床》2022年第5期736-741,794,共7页Labeled Immunoassays and Clinical Medicine

摘　　要：目的研究丙型肝炎病毒抗体阳性患者丙型肝炎病毒抗体(HCV-Ab)、丙型肝炎病毒核糖核酸(HCV-RNA)及丙氨酸氨基转移酶(ALT)检测结果分布特点及相关性。方法收集北京同仁医院2018年1月至2021年6月HCV-Ab阳性患者HCV-Ab、HCV-RNA、ALT检测数据,运用统计学方法分析三者数据分布特点及相关性,以及HCV-RNA阳性患者与HCV-RNA阴性患者HCV-Ab检测值与ALT水平分布特点。结果患者个体HCV-Ab检测值、HCV-RNA与ALT水平三者之间不存在明显的相关性,但将三者实验数据按检测值的高低、阴阳性以及异常率进行分组仍然存在一定的规律。HCV-RNA阳性患者的HCV-Ab检测值高于阴性患者,预测HCV-RNA阳性的最佳HCV-Ab阈值为10.34(S/CO)。患者ALT异常率、HCV-RNA阳性率随HCV-Ab检测值分组的升高有升高的趋势。ALT异常率与患者HCV-RNA阴阳性有关,但与HCV-RNA水平分组无关。结论患者HCV-Ab检测值对预测HCV-RNA阴阳性有较大的应用价值,HCV-Ab检测值升高和HCV-RNA阳性的患者发生ALT异常的可能性更大,临床可对三者实验结果进行预判和印证。Objective To study the distribution and correlation of hepatitis C virus antibody(HCV-Ab),hepatitis C virus RNA(HCV-RNA)and alanine aminotransferase(ALT)in patients with positive hepatitis C virus antibody.Methods The test data of HCV-Ab,HCV-RNA and ALT in HCV-Ab positive patients in Beijing Tongren Hospital from January,2018 to June,2021 were collected for the study.The data distribution characteristics and correlation among the three were analyzed by statistical methods,as well as the horizontal distribution characteristics of HCV-Ab test values and ALT concentrations in HCV-RNA positive patients and HCV-RNA negative patients.Results There was no significant correlation among individual HCV-Ab test value,HCV-RNA concentration and ALT concentration,while there was an observed pattern to group the three according to the test value,based on negative,positive and abnormal rate.HCV-Ab test value of HCV-RNA positive patients was higher than that of HCV-RNA negative patients.The threshold of the best HCV-Ab test value for predicting HCV-RNA positive was 10.34(S/CO).The abnormal rate of ALT and the positive rate of HCV-RNA increased with the increase of HCV-Ab test value.The abnormal rate of ALT was related to the negative and positive of HCV-RNA,but not to the grouping of HCV-RNA concentration.Conclusion The detection value of HCV-Ab has effective application value in predicting HCV-RNA negative and positive.Patients with higher detection value of HCV-Ab and patients with positive HCV-RNA are more likely to have abnormal ALT.Clinically,clinicians can predict and confirm the experimental results of the three.

关 键 词：丙型肝炎病毒抗体 丙型肝炎病毒核糖核酸 丙氨酸氨基转移酶 

分 类 号：R512.63[医药卫生—内科学]