乳糜腹患者腹腔感染病原菌分布及耐药性分析  

The Distribution and Drug Resistance of Pathogens Causing Abdominal Infection in Patients with Chylous Ascites

作　　者：庞婷[1] 王蕾[1] 鲍中英[1] 张捷[1] 段淑红[1] 薛文英 PANG Ting;WANG Lei;BAO Zhongying;ZHANG Jie;DUAN Shuhong;XUE Wenying(Department of Infectious Diseases,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Health Care Office,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属北京世纪坛医院感染科,北京100038 [2]首都医科大学附属北京世纪坛医院干部保健办公室,北京100038

出　　处：《标记免疫分析与临床》2022年第5期807-809,835,共4页Labeled Immunoassays and Clinical Medicine

基　　金：北京市保健课题项目(编号:京19-1号)。

摘　　要：目的分析乳糜腹患者腹腔感染病原菌的分布及耐药性,为临床合理选择抗感染药物提供参考。方法回顾性分析2016年1月至2021年5月北京世纪坛医院乳糜腹住院患者病例资料和送检腹腔积液的病原菌培养和药敏试验结果。结果2016年1月至2021年5月腹腔积液培养阳性的乳糜腹患者共27例,分离菌株共37株。其中革兰阳性菌20株(54.05%),主要为肠球菌属和葡萄球菌属,检出3株MRCNS和1株MRSA,革兰阳性菌对万古霉素、利奈唑胺高度敏感。革兰阴性菌16株(43.24%),肠杆菌科9株,非发酵菌6株(37.5%),检出1株产ESBLs大肠埃希菌,革兰阴性菌对厄他培南、美罗培南、头孢哌酮钠舒巴坦钠敏感率高。真菌1株(2.7%),为白色假丝酵母菌。结论乳糜腹患者腹腔感染病原菌种类较多,革兰阳性菌略高,革兰阳性菌主要以肠球菌属和葡萄球菌属为主,革兰阴性菌中以肠杆菌为主,临床应合理选择抗菌药物。Objective To analyze the distribution and drug resistance of pathogens causing abdominal infection in patients with chylous ascites,and to provide a reference for clinical rational during the selection of antibacterial drug.Methods The clinical data of hospitalized patients with chylous ascites in Beijing Shijitan Hospital from January,2016 to May,2021 were retrospectively analyzed,and the results of pathogenic bacteria culture and drug sensitivity test of ascites were analyzed.Results From January,2016 to May,2021,37 strains were isolated from 27 patients with positive ascites culture.Among them,20 strains(54.05%)of Gram-positive bacteria were mainly Enterococcus and Staphylococcus,and 3 MRCNS and 1 MRSA were detected.Gram-positive bacteria were highly sensitive to vancomycin and linezolid.There were 16 strains of Gram-negative bacteria(43.24%),9 strains of Enterobacteriaceae,6 strains of non-fermenting bacteria(37.5%),and 1 strain of ESBLs-producing Escherichia coli.Gram-negative bacteria were highly sensitive to ertapenem,meropenem,and cefoperazone sodium and sulbactam sodium.1 isolated(2.7%)strain was Candida albicans.Conclusion There are many types of pathogens causing abdominal infection in patients with chylous ascites.Gram-positive bacteria are slightly higher.Gram-positive bacteria are mainly Enterococcus and Staphylococcus,while Gram-negative bacteria are mainly Enterobacter.Antibiotics should be rationally selected.

关 键 词：乳糜腹 腹腔感染 病原菌 耐药性 分析 

分 类 号：R378[医药卫生—病原生物学]