131I和抗甲状腺药物治疗甲亢的疗效观察  

Efficacy observation of iodine-13 and antithyroid drugs in the treatment of hyperthyroidism

作　　者：刘佳 LIU Jia(People's Hospital of Lyushunkou District,Dalian 116041,China)

机构地区：[1]辽宁省大连市旅顺口区人民医院,116041

出　　处：《中国现代药物应用》2022年第11期107-110,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析碘131(^(131)I)和抗甲状腺药物治疗甲状腺功能亢进症(甲亢)的临床疗效。方法76例甲亢患者,根据治疗方式不同分为常规组和研究组,各38例。常规组患者采用抗甲状腺药物治疗,研究组患者采取碘131治疗。比较两组临床疗效、复发情况、并发症发生情况及甲状腺激素[四碘甲状腺原氨酸(T_(4))、游离三碘甲状原氨酸(FT_(3))、三碘甲状腺原氨酸(T_(3))、游离甲状腺素(FT_(4))]水平。结果研究组治疗总有效率97.37%高于常规组的78.95%,复发率2.70%低于常规组的26.67%,差异有统计学意义(P<0.05)。研究组并发症发生率5.26%低于常规组的26.32%,差异有统计学意义(P<0.05)。治疗后,研究组T_(3)(2.26±1.22)nmol/L、T_(4)(85.81±5.75)nmol/L、FT_(4)(13.18±3.25)pmol/L、FT_(3)(6.56±2.29)pmol/L均低于常规组的(3.94±1.09)nmol/L、(98.78±4.01)nmol/L、(16.23±3.71)pmol/L、(8.19±2.51)pmol/L,差异有统计学意义(P<0.05)。结论使用碘131治疗甲亢患者的临床效果明显比抗甲状腺药物治疗效果显著,能够有效减少并发症,缓解临床相关指标,值得推广。Objective To analyze the clinical efficacy of iodine-13(^(131)I)and antithyroid drugs in the treatment of hyperthyroidism.Methods A total of 76 patients with hyperthyroidism were divided into conventional group and research group according to different treatment methods,with 38 cases in each group.Patients in the conventional group were treated with antithyroid drugs,and patients in the research group were treated with iodine-13.The clinical efficacy,recurrence,complications and thyroid hormones[tetraiodothyronine(T_(4)),free triiodothyronine(FT_(3)),triiodothyronine(T_(3)),free thyroid prime(FT_(4))]levels.Results The total effective rate 97.37%of the research group was higher than 78.95% of the conventional group,and the recurrence rate 2.70%was lower than 26.67% of the conventional group.All the differences were statistically significant(P<0.05).The complication rate 5.26% in the research group was lower than 26.32% in the routine group,and the difference was statistically significant(P<0.05).After treatment,the T_(3)(2.26±1.22)nmol/L,T_(4)(85.81±5.75)nmol/L,FT_(4)(13.18±3.25)pmol/L,FT_(3)(6.56±2.29)pmol/L in the research group were all lower than(3.94±1.09)nmol/L,(98.78±4.01)nmol/L,(16.23±3.71)pmol/L,(8.19±2.51)pmol/L in the conventional group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of iodine-13 in the treatment of patients with hyperthyroidism is significantly better than that of antithyroid drugs,which can effectively reduce the complications and relieve the clinical related indicators,and is worthy of promotion.

关 键 词：甲状腺功能亢进症 碘131 抗甲状腺药物 并发症 

分 类 号：R581.1[医药卫生—内分泌]