混合核苷片在急性胰腺炎大鼠细胞免疫调节中的作用研究  

The research on the effect of mixed nucleoside tablets in cellular immune regulation of rats with acute pancreatitis

作　　者：章诺贝[1] 沈浩[1] 刘惠芳[1] ZHANG Nuo-bei;SHEN Hao;LIU Hui-fang(Department of Gastroenterology,Second Affiliated Hospital of Nanchang University,Nanchang 330000,China)

机构地区：[1]南昌大学第二附属医院消化科,330000

出　　处：《中国现代药物应用》2022年第11期190-193,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 评估早期使用混合核苷片对急性胰腺炎(AP)大鼠免疫调节的影响。方法 48只AP大鼠,随机分为混合核苷片组和对照组,每组24只。混合核苷片组大鼠给予混合核苷片喂服,对照组大鼠给予相同质量的淀粉喂服。在第0、15、30天测量大鼠主要组织相容性复合体Ⅰ类(AgBⅠ)水平和T淋巴细胞免疫参数。结果 组内比较:对照组大鼠第0、15、30天CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、AgBⅠ组内比较差异均无统计学意义(P>0.05)。混合核苷片组大鼠第15、30天CD3^(+)、CD4^(+)、CD8^(+)、AgBⅠ均高于本组第0天,差异均具有统计学意义(P<0.05);混合核苷片组大鼠第15、30天CD4^(+)/CD8^(+)有所增加,但组内不同时间点比较差异无统计学意义(P>0.05)。组间比较:第0天,两组大鼠CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、AgBⅠ组间比较差异均无统计学意义(P>0.05)。第15、30天,混合核苷片组大鼠CD3^(+)、CD4^(+)、CD8^(+)、AgBⅠ均高于对照组,差异具有统计学意义(P<0.05);两组大鼠CD4^(+)/CD8^(+)比较差异无统计学意义(P>0.05)。第15天,混合核苷片组脓毒症、腹腔内脓肿发生率分别为8.33%、4.17%,均低于对照组的50.00%、66.67%,差异具有统计学意义(P<0.05);第30天,混合核苷片组脓毒症、腹腔内脓肿发生率分别为4.17%、4.17%,均低于对照组的83.33%、83.33%,差异具有统计学意义(P<0.05)。混合核苷片组死亡率为8.33%,低于对照组的70.83%,差异具有统计学意义(P<0.05)。结论 混合核苷片可提高细胞诱导的免疫力,降低AP大鼠的感染率及死亡率。Objective To evaluate the effect of mixed nucleoside tablets in cellular immune regulation of rats with acute pancreatitis(AP).Methods A total of 48 AP rats were randomly divided into mixed nucleoside tablet group and control group,with 24 rats in each group.Rats in the mixed nucleoside tablet group took mixed nucleoside tablets,and rats in the control group took starch of the same quality.The major histocompatibility leukocyte antigen(AgBⅠ)levels and T lymphocyte immune parameters were measured on days 0,15,and 30 in rats.Results Comparison within groups:there was no statistically significant difference in CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and AgBⅠin the control group on days 0,15,and 30(P>0.05).The CD3^(+),CD4^(+),CD8^(+),and AgBⅠof the mixed nucleoside tablet group increased with time,and the differences within the group were statistically significant(P<0.05).The CD4^(+)/CD8^(+)in the mixed nucleoside tablet group increased on days 15 and 30,but the differences were not statistically significant when comparing different time points within the group(P>0.05).Comparison between groups:On day 0,there was no statistically significant difference in CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and AgBⅠbetween the two groups(P>0.05).On days 15 and 30,the CD3^(+),CD4^(+),CD8^(+),and AgBⅠin the mixed nucleoside tablet group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in CD4^(+)/CD8^(+)between the two groups(P>0.05).On day 15,the incidences of sepsis and intra-abdominal abscess in the mixed nucleoside tablet group were 8.33% and 4.17%,which were lower than 50.00% and 66.67%in the control group,and the differences were statistically significant(P<0.05).On day 30,the incidences of sepsis and intra-abdominal abscess in the mixed nucleoside tablet group were 4.17% and 4.17%,which were lower than 83.33% and 83.33% in the control group,and the differences were statistically significant(P<0.05).The mortality r

关 键 词：混合核苷片 急性胰腺炎 细胞免疫 主要组织相容性复合体Ⅰ类 

分 类 号：R965[医药卫生—药理学]