宫腹腔镜-来曲唑对子宫内膜异位症患者血清炎症因子及ENA-78、MCP-1的影响  

Effects of uterine laparoscopy-letrozole on serum inflammatory factors,ENA-78 and MCP-1 in patients with endometriosis

作　　者：马翠 自辉 薛潇 MA Cui;ZI Hui;XUE Xiao(Department of Obstetrics,Zaozhuang Maternal and Child Health Hospital,Zaozhuang 277100,Shandong,China)

机构地区：[1]枣庄市妇幼保健院产科,山东省枣庄市277100

出　　处：《中南医学科学杂志》2022年第5期747-749,共3页Medical Science Journal of Central South China

摘　　要：目的 分析宫腹腔镜-来曲唑对子宫内膜异位症(EM)患者血清炎症因子及中性粒细胞活化肽78(ENA-78)、单核细胞趋化因子-1(MCP-1)水平的影响。方法 EM患者200例均分为对照组(宫腹腔镜手术)和联合组(宫腹腔镜手术联合来曲唑)。采用放射免疫法检测血清黄体生成素(LH)、促卵泡激素(FSH)和雌二醇(E2),酶联免疫吸附测定法检测血清炎症因子白细胞介素-2(IL-2)、IL-10、C反应蛋白(CRP)和ENA-78、MCP-1。结果 联合组治疗总有效率明显高于对照组(P<0.05)。与治疗前比较,两组治疗后血清LH、FSH、E2、IL-2、IL-10、CRP、ENA-78和MCP-1水平均明显降低(P<0.05),且联合组治疗后上述指标均显著低于对照组(P<0.05)。结论 宫腹腔镜-来曲唑治疗EM临床效果明显,且能明显降低血清炎症因子及ENA-78、MCP-1水平。Aim To analyze the effect of uterine laparoscopy-letrozole on serum inflammatory factors,neutrophil-activated peptide 78(ENA-78)and monocyte chemokine-1(MCP-1)levels in patients with endometriosis(EM).Methods 200 EM patients were divided into the control group(uterine laparoscopic surgery)and the combined group(u-terine laparoscopic surgery combined with letrozole).Serum luteinizing hormone(LH),follicle-stimulating hormone(FSH),and estradiol(E2)were detected by radioimmunoassay,and serum inflammatory factor interleukin-2(IL-2),IL-10,C reactive protein(CRP),and ENA-78,MCP-1 were measured by enzyme-linked immunosorbent assay.Results The total effectiverate in the combinedgroup was significantly higher than that in the control group(P<0.05).Compared with the pre-treatment levels,the serum LH,FSH,E2,IL-2,IL-10,CRP,ENA-78,and MCP-1 levels were significantly decreased after treatment in both groups(P<0.05),and the above indicators in the combined group were sig-nificantly lower than control group(P<0.05).Conclusion Uterine laparoscopic-letrozole has obvious clinical effect in the treatment of EM,and can significantly reduce the levels of serum inflammatory factors,ENA-78,and MCP-1.

关 键 词：子宫内膜异位症 来曲唑 宫腹腔镜 炎症因子 中性粒细胞活化肽-78 单核细胞趋化因子-1 

分 类 号：R711.71[医药卫生—妇产科学]