基于金纳米笼的控释给药系统研究进展  

Research Progress of Controlled-Release Drug Delivery Systems Based on Gold Nanocages

作　　者：李春明 赵腾月 陈万一 LI Chunming;ZHAO Tengyue;CHEN Wanyi(Chongqing University Cancer Hospital,Chongqing,China 400030;Zhengzhou University,Zhengzhou,Henan,China 450001)

机构地区：[1]重庆大学附属肿瘤医院,重庆400030 [2]郑州大学,河南郑州450001

出　　处：《中国药业》2022年第14期128-128,I0001-I0005,共6页China Pharmaceuticals

基　　金：重庆市自然科学基金面上项目[cstc2019jcyj-msxmX0035];重庆市临床药学重点专科建设项目。

摘　　要：目的为控释给药系统的功能化修饰与应用提供参考。方法检索基于金纳米笼(AuNCs)的控释给药系统相关文献,分析不同类别该系统的制备方法、释药机制及意义。结果与结论可利用温度、激光、核糖核酸(RNA)、酶、pH等作为刺激因子制备系列单一及联合刺激响应控释型给药系统。在实现药物的精准控释方面,与单一刺激响应控释型AuNCs比较,联合刺激响应控释型AuNCs给药系统意义更大,机制更复杂,需进一步研究。Objective To provide a reference for the functional modification and application of controlled-release drug delivery systems.Methods The literature related to controlled-release drug delivery systems based on gold nanocages(AuNCs)were reviewed,and the preparation methods,drug release mechanisms and significance of different types of AuNCs were analyzed.Results and Conclusion A series of single and combined stimuli-responsive controlled-release drug delivery systems can be prepared with temperature,laser,RNA,enzyme and pH as stimulation factors.Compared with the single stimuli-responsive controlled-release AuNCs,the combined stimuli-responsive controlled-release AuNCs delivery systems are of greater significance to achieve precise drug delivery,and their mechanisms are also more complex,which need further research.

关 键 词：金纳米笼 刺激因子 给药系统 控释给药 进展 

分 类 号：R944[医药卫生—药剂学]