缺血性心衰与非缺血性心衰血浆致动脉粥样硬化指数、平均血小板体积与心功能的关系  

The Relationship Between Ischemic Heart Failure and Nonischemic Heart Failure Plasma Arteriosclerosis Index,Mean Platelet Volume and Cardiac Function

作　　者：祝小涵 邵磊[1] 海冰峰[1] ZHU Xiaohan;SHAO Lei;HAI Bingfeng(Department of Cardiology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450014)

机构地区：[1]郑州大学第二附属医院心内科,河南郑州450014

出　　处：《智慧健康》2022年第11期93-97,共5页Smart Healthcare

摘　　要：目的 研究缺血性与非缺血性心衰患者中血浆致动脉粥样硬化指数(AIP)和平均血小板体积(MPV)与心功能(射血分数EF值)的关系和诊断价值。方法 收集入院确诊为心衰的患者140例,根据是否伴有缺血,分为缺血性心衰组(实验组)和非缺血性心衰心衰组(对照组),比较两组的年龄、BMI、糖尿病史、高血压、吸烟史等临床指标。血生化检测指标包括平均血小板体积(MPV)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、血小板、血糖、白细胞、收缩压、舒张压。心功能检测指标为射血分数(EF%)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD),计算出血浆致动脉粥样硬化指数(AIP),分析AIP、MPV与心功能的关系及诊断价值。结果 缺血性心衰组AIP、MPV水平高于对照组(P <0.05);多因素Logisitic回归分析显示AIP、MPV均是缺血性心衰的独立预测指标,其中AIP(β=-14.74,95%CI:-27.935~-1.546,P <0.05),MPV(β=-2.158,95%CI:-4.029~-1.007,P <0.05);在ROC曲线分析中,MPV的曲线下面积为0.686,截止水平为10.45时,敏感度达到77.9%,诊断缺血性心衰的特异性为54%。AIP诊断缺血性心衰的节点值为0.93,ROC曲线下面积为0.614,敏感性为84.4%,特异性为38.1%。结论 缺血性心衰中AIP、MPV均高于对照组,AIP、MPV均是缺血性心衰的独立预测因子,与EF值独立负相关,具有诊断心衰的临界值。Objective To study the relationship and diagnostic value of plasma arteriosclerosis index(AIP), mean platelet volume(MPV) and cardiac function(ejection fraction EF value) in patients with ischemic and non-ischemic heart failure. Methods A total of 140 patients diagnosed with heart failure were collected and divided into ischemic heart failure group(experimental group) and nonischemic heart failure group(control group) according to whether they were accompanied by ischemia.The two groups were compared. Clinical indicators such as age, BMI, history of diabetes, high blood pressure, and smoking history. Blood biochemical test indicators include mean platelet volume(MPV),low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), triglycerides(TG), platelets, blood sugar, white blood cells, systolic blood pressure, Diastolic blood pressure. Cardiac function test indicators are ejection fraction(EF%), left ventricular end systolic diameter(LVESD), left ventricular end diastolic diameter(LVEDD), calculate the plasma arteriosclerosis index(AIP), analyze the relationship between AIP, MPV and cardiac function Relationship and diagnostic value. Results The levels of AIP and MPV in the ischemic heart failure group were higher than those in the control group(P <0.05);multivariate Logisitic regression analysis showed that both AIP and MPV were independent predictors of ischemic heart failure, and AIP(β=-14.74),95%CI:-27.935~-1.546, P<0.05), MPV(β=-2.158,95%CI:-4.029~-1.007, P <0.05);In the ROC curve analysis, the area under the curve of MPV is 0.686, when the cut-off level is 10.45, the sensitivity reaches 77.9%, and the specificity for diagnosing ischemic heart failure is 54%. The cut-off value of AIP for the diagnosis of ischemic heart failure was 0.93, the area under the ROC curve was 0.614, the sensitivity was 84.4%, and the specificity was 38.1%. Conclusion AIP and MPV in ischemic heart failure are higher than those in the control group. Both AIP and MPV are independent predictors of ischem

关 键 词：缺血性心衰 血浆致动脉粥样硬化指数 平均血小板体积 心功能 

分 类 号：R541.6[医药卫生—心血管疾病] R543.5[医药卫生—内科学]