奥玛株单抗在慢性鼻窦炎伴鼻息肉患者治疗中的应用  

Application of omalzumab in patients with chronic sinusitis with nasal polyp type

作　　者：黄僖 周建波[1] HUANG Xi;ZHOU Jianbo(Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Hunan Normal University,Hunan Provincial People’s Hospital,Changsha 410005,China)

机构地区：[1]湖南师范大学附属第一医院湖南省人民医院耳鼻咽喉头颈外科,湖南长沙410005

出　　处：《中国耳鼻咽喉颅底外科杂志》2022年第3期111-115,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：慢性鼻窦炎伴鼻息肉(CRSwNP)的炎症机制复杂,现有治疗方式对其病情控制欠佳。奥玛株单抗可通过与IgE受体结合降低患者的免疫级联反应,已有研究证明其对缓解CRSwNP合并哮喘患者的鼻部症状有良好的效果,但针对伴嗜酸性粒细胞增多、IgE水平高的难治性复发性CRSwNP治疗效果的探索还需要更多、更大规模的随机对照实验来证明。本文结合该背景对奥玛株单抗的作用机制以及在CRSwNP中的应用进行阐述,为CRSwNP的治疗提供参考。The inflammatory mechanism of chronic sinusitis with nasal polyp type(CRSwNP) is complex, and existing treatments are ineffective in controlling the disease. Omalizumab reduces the immune cascade by binding to IgE receptors in patients with CRSwNP. Omalizumab has been proved to be effective in alleviating nasal symptoms in patients with asthma complicated with CRSwNP. However, the efficacy of omalizumab in refractory relapsing CRSwNP with eosinophilia and high IgE levels needs to be demonstrated in more and larger randomized controlled trials. In this paper, the application and the mechanism of omalizumab in patients with CRSwNP with asthma, which was described in combination with this background, so as to provide reference for the treatment of CRSwNP.

关 键 词：慢性鼻窦炎伴鼻息肉型 慢性鼻窦炎 奥玛株单抗 抗IGE抗体 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]