高剂量丙基硫氧密啶治疗妊娠合并甲亢的效果及对其肝功能的影响  

Effect of High Dose Propylthiomidine on Pregnancy Complicated with Hyperthyroidism and its Influence on Liver Function

作　　者：彭育泉 罗伟梅 林翠 PENG Yuquan;LUO Weimei;LIN Cui(Xingning maternal and child health and family planning service center,internal medicine,Xingning,Guangdong 514500)

机构地区：[1]兴宁市妇幼保健计划生育服务中心内科,广东兴宁514500

出　　处：《智慧健康》2022年第8期92-94,共3页Smart Healthcare

摘　　要：目的研究分析高剂量丙基硫氧密啶治疗妊娠合并甲亢的效果及对其肝功能的影响。方法选取2019年1月-2021年1月期间于我院治疗的111例妊娠合并甲亢患者为研究对象,按照随机数字表法均分为对照组(n=55)与试验组(n=56)并给予不同剂量(对照组150mg,试验组300mg)丙基硫氧密啶进行治疗,比较两组治疗效果、治疗前后促甲状腺激素(TSH)、谷氨酸转氨酶(ALT)、总胆红素(TBIL)、碱性磷酸酶(ALP)、纤维蛋白原(FIB)及妊娠结局。结果试验组治疗总有效率明显高于对照组(P<0.05)。试验组治疗后TSH、ALT、TBIL、ALP高于对照组(P<0.05),试验组治疗后FIB低于对照组(P<0.05)。试验组治疗后不良妊娠结局发生率低于对照组(P<0.05)。结论高剂量丙基硫氧密啶治疗妊娠合并甲亢的效果良好,可改善患者血液高凝情况并降低妊娠不良结局发生率,但是对患者肝功能有一定损伤。Objective To study and analyze the effect of high-dose propylthiomidine in the treatment of pregnancy complicated with hyperthyroidism and its influence on liver function.Methods 111 cases of pregnant women with hyperthyroidism treated in our hospital from January 2019 to January 2021 were selected as the research objects.According to the random number table method,they were divided into control group(n=55)and experimental group(n=56)and given different doses of propylthiomidine(150 mg in the control group and 300 mg in the experimental group).The therapeutic effect,thyroid stimulating hormone(TSH)and glutathione before and after treatment were compared between the two groups Alanine aminotransferase(ALT),total bilirubin(TBIL),alkaline phosphatase(ALP),fibrinogen(FIB)and pregnancy outcome.Results The total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).After treatment,TSH,alt,TBIL and ALP in the experimental group were higher than those in the control group(P<0.05),and Fib in the experimental group was lower than that in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the experimental group was lower than that in the control group(P<0.05).Conclusion High dose of propylthiomidine in the treatment of pregnancy with hyperthyroidism has a good effect,can improve the blood hypercoagulability and reduce the incidence of adverse pregnancy outcomes,but has certain damage to the liver function of patients.

关 键 词：妊娠合并甲亢 肝功能 高剂量 丙基硫氧密啶 

分 类 号：R714.256[医药卫生—妇产科学]