TSH、TPOAb、TRAb、TG-Ab等多种抗体检测在甲状腺疾病诊断中的意义  

Significance of TSH,TPOAb,TR-Ab,TG AB and other Antibodies in the Diagnosis of Thyroid Diseases

作　　者：刘志东[1] 缪海婷[1] LIU Zhidong;MIAO Haiting(Laboratory Department,Dongguan People’s Hospital,Dongguan,Guangdong,523000)

机构地区：[1]东莞市人民医院检验科,广东东莞523000

出　　处：《智慧健康》2022年第16期5-8,共4页Smart Healthcare

摘　　要：目的研究促甲状腺素(thyroid stimulating hormone,TSH)、甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)、促甲状腺素受体抗体(Thyrotropin receptor antibodies,TRAb)及抗甲状腺球蛋白抗体(anti-thyroglobulin antibodies,TG-Ab)等多种抗体检测对甲状腺疾病诊断的临床意义。方法取2018年1月-2020年10月就诊于东莞市人民医院的甲状腺疾病患者200例,其中含自身免疫性甲状腺疾病患者102例(自免组)及非自身免疫性甲状腺疾病患者98例(非自免组),同时选取100例同期健康体检成人作为对照组,比较三组年龄、性别等一般资料,比较患者血清中TSH、TPOAb、TRAb及TG-Ab的浓度,并对其诊断价值进行分析。结果三组患者的年龄、性别一般指标间比较,差异无统计学意义(P>0.05);自免组患者血清中的TSH、TPOAb、TRAb及TG-Ab水平明显高于非自免组患者及对照组患者,且非自免组患者血清中的TSH、TPOAb、TRAb及TG-Ab水平明显高于对照组,差异均有统计学意义(P<0.05);自免组患者的TSH、TPOAb、TRAb及TG-Ab阳性率及浓度均显著高于其他两组患者,差异有统计学意义(P<0.05),且在自免组患者中TSH、TRAb的特异性、灵敏度、准确性均显著优于TPOAb及TG-Ab,差异有统计学意义(P<0.05)。结论TSH及TRAb检测在自身免疫性甲状腺疾病诊断中具有较高的准确性、灵敏度及特异性,能提高临床患者的诊断率,值得推广。Objective To study the clinical significance of multiple antibody detection in the diagnosis of thyroid diseases,such as thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPOAb),thyrotropin receptor antibodies(TRAb)and anti thyroglobulin antibodies(TG-Ab).Methods 200 patients with thyroid diseases in our hospital from January 2018 to October 2020 were selected,including 102 patients with autoimmune thyroid diseases(autoimmune group)and 98 patients with non autoimmune thyroid diseases(non autoimmune group).At the same time,100 healthy adults in the same period were selected as the control group,and the age,gender and other general data of the three groups were compared,The serum concentrations of TSH,TPOAb,TRAb and TG-AB were compared,and their diagnostic value was analyzed.Results There was no significant difference in age and gender among the three groups(all P>0.05);The serum levels of TSH,TPOAb,TRAb and TG-AB in the autoimmune group were significantly higher than those in the non autoimmune group and the control group,and the serum levels of TSH,TPOAb,TRAb and TG-AB in the non autoimmune group were significantly higher than those in the control group(all P<0.05);The positive rates and concentrations of TSH,TPOAb,TRAb and TG-AB in the autoimmune group were significantly higher than those in the other two groups(all P<0.05),and the specificity,sensitivity and accuracy of TSH and TRAb in the autoimmune group were significantly better than TPOAb and TG-AB(all P<0.05).Conclusion TSH and TRAb have high accuracy,sensitivity and specificity in the diagnosis of autoimmune thyroid diseases.They can improve the diagnostic rate of clinical patients and a re worthy of popularization.

关 键 词：甲状腺抗体 自身免疫性甲状腺疾病 非自身免疫性甲状腺疾病 敏感性 

分 类 号：R581[医药卫生—内分泌] R446.6[医药卫生—内科学]