磁共振动态增强与血清肝细胞生长因子受体c-Met和结肠癌转移相关基因1联合检测在宫颈癌盆腔淋巴结转移的价值  

Value of DCE-MRI combined with the detections of serum c-Met and MACC1 in pelvic lymph node metastasis of cervical cancer

作　　者：张梯勇 陈文 陈晓雷 舒源河 ZHANG Ti-yong;CHEN Wen;CHEN Xiao-lei(不详;Department of Radiology,Qianjiang Central Hospital of Chongqing,Chongqing 409000,China)

机构地区：[1]重庆市黔江中心医院放射科,重庆409000

出　　处：《中国医学装备》2022年第7期58-62,共5页China Medical Equipment

基　　金：重庆市卫生健康委员会科研项目(2019HBRC016)“磁共振功能成像在宫颈癌检测中的应用研究价值”。

摘　　要：目的:分析磁共振动态增强扫描成像(DCE-MRI)与血清肝细胞生长因子(HGF)受体c-Met、结肠癌转移相关基因1(MACC1)联合检测对宫颈癌(CC)盆腔淋巴结转移的诊断价值。方法:选取医院收治的124例CC患者,根据其发生盆腔淋巴结转移与否分为淋巴结未转移组(88例,简称未转移组)和淋巴结转移组(36例,简称转移组)。所有患者均行DCE-MRI检查、血清c-Met及MACC1水平检测;以患者术后组织病理学检查为“金标准”,分析DCE-MRI检查、血清c-Met、MACC1检测及三者联合诊断对CC患者盆腔淋巴结转移的诊断效能。结果:转移组中DCE-MRI评估患者盆腔淋巴结转移的灵敏度为77.78%,特异度为93.18%,准确度为88.71%;血清c-Met及MACC1水平均高于未转移组,差异有统计学意义(t=10.466,t=9.267;P<0.05);血清c-Met和MACC1诊断盆腔淋巴结转移的受试者工作特征(ROC)曲线下面积(AUC)分别为0.893和0.879,截断值分别为104.23μg/L和6.70 ng/ml,灵敏度、特异度分别为83.33%和80.56%,89.77%和90.91%,准确率均为87.90%;DCE-MRI与血清c-Met、MACC1联合诊断患者盆腔淋巴结转移的灵敏度及准确率分别为94.44%和90.32%,均高于三者单独检测,差异有统计学意义(x^(2)=4.181,P<0.05)。结论:DCE-MRI联合血清c-Met、MACC1检测对CC盆腔淋巴结转移有较高的诊断价值,三者联合可显著提高灵敏度,有助于临床判定CC盆腔淋巴结转移。Objective:To analyze the diagnostic value that dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with serum hepatocyte growth factor(HGF)receptor c-Met and metastasis-associated in colon cancer 1(MACC1)for pelvic lymph node metastasis of cervical cancer(CC).Methods:A total of 124 CC patients admitted to hospital were selected as the research subjects.They were divided into lymph node non-metastasis group(88 cases)and lymph node metastasis group(36 cases)according to whether occurred pelvic lymph node metastasis.All CC patients underwent DCE-MRI examination,serum c-Met and MACC1 detection.The histopathological examination after surgery for CC patients was used as golden standard to analyze the diagnostic efficiencies of DCE-MRI examination,serum c-Met detection,serum MACC1 detection and the combined diagnosis of above three methods for pelvic lymph node metastasis of CC patients.Results:The sensitivity,specificity and accuracy of DCE-MRI of lymph node metastasis group were 77.78%,93.18%and 88.71%in assessing pelvic lymph node metastasis of CC patients,and the levels of serum c-Met and MACC1 of metastasis group were significantly higher than those of non-metastasis group(t=10.466,t=9.267,P<0.05).The area under the curve(AUC)of receiver operating characteristics(ROC)of serum c-Met and MACC1 were 0.893 and 0.879,respectively,in diagnosing pelvic lymph node metastasis,and the cut-off values of them were 104.23μg/L and 6.70 ng/mL,respectively.In addition,the sensitivities and specificities of them were(83.33%and 80.56%)and(89.77%and 90.91%),respectively,and the accuracies both them were 87.90%.The sensitivity and accuracy of the combined diagnosis of DCE-MRI and serum c-Met and MACC1 were 94.44%and 90.32%in diagnosing pelvic lymph node metastasis of CC patients,respectively,and both of them were significantly higher than those of each single detection(x^(2)=4.181,P<0.05).Conclusion:The detection of DCE-MRI combined with serum c-Met and MACC1 has higher diagnostic value for pelvic lymph node metasta

关 键 词：宫颈癌(CC) 肝细胞生长因子(HGF)受体c-Met 磁共振动态增强扫描成像(DCE-MRI) 结肠癌转移相关基因1(MACC1) 盆腔淋巴结转移 

分 类 号：R445.2[医药卫生—影像医学与核医学]