熊去氧胆酸辅助胆道镜治疗肝内外胆管结石的效果  

Effect of Ursodeoxycholic Acid Assisted Cholangioscopy in the Management of Intrahepatic and Extrahepatic Cholangiolithiasis

作　　者：黄黄叶 林秀楠 黄志耿 HUANG Huangye;LIN Xiunan;HUANG Zhigeng(Department of General Surgery,Puning Overseas Chinese Hospital,Jieyang,Guangdong,515300)

机构地区：[1]普宁华侨医院普通外科,广东揭阳515300

出　　处：《智慧健康》2022年第14期30-32,共3页Smart Healthcare

摘　　要：目的 探讨熊去氧胆酸辅助胆道镜治疗肝内外胆管结石的效果。方法 选择2018年1月-2020年6月普宁华侨医院收治的60例肝内外胆管结石患者作为研究对象,采用随机数字法分为对照组和观察组,对照组29例给予腹腔镜下行纤维胆道镜治疗,观察组31例在对照组基础上再给予熊去氧胆酸治疗。观察治疗后两组临床疗效、肝功能相关指标、术后胆管结石复发率。结果 治疗后,观察组的治疗总有效率为96.77%高于对照组的79.31%(P<0.05);观察组总胆汁酸(TBA)高于对照组,胆固醇(CHO)、天冬氨酸转氨酶(AST)、谷丙氨酸转氨酶(ALT)低于对照组(P<0.05);观察组的术后复发率为3.23%低于对照组的24.14%(P<0.05)。结论 熊去氧胆酸联合胆道镜治疗肝内外胆管结石临床疗效显著,有助于改善肝胆功能,减少胆汁淤积,防止肝胆结石复发,促进良好预后。Objective To investigate the effect of ursodeoxycholic acid assisted cholangioscopy in the treatment of intrahepatic and extrahepatic bile duct stones.Methods A total of 60 patients with intrahepatic and extrahepatic cholangiolithiasis treated in our hospital from January 2018 to June 2020 were selected as study subjects and divided into control and observation groups by random digit method,29 patients in control group were given laparoscopic descending fiberoptic cholangioscopy treatment,and 31 patients in observation group were given ursodeoxycholic acid treatment on the basis of control group again.The clinical outcomes,liver function related indexes,and the recurrence rate of postoperative bile duct stones in the two groups after treatment were observed.Results After treatment,the overall response rate of 96.77% of treatment in the observation group was higher than the 79.31% in the control group (P<0.05);In the observation group,total bile acids (TBA) were higher,cholesterol (CHO),aspartate transaminase (AST),and glutathione transaminase (ALT) were lower (P<0.05) than in the control group;The postoperative recurrence rate of 3.23% in the observation group was lower than 24.14% in the control group (P<0.05).Conclusions Ursodeoxycholic acid combined with cholangioscopy has a remarkable clinical effect in the treatment of intrahepatic and extrahepatic cholangiolithiasis,which helps to improve hepatobiliary function,reduce cholestasis,prevent recurrence of hepatobiliary stones and promote a good prognosis.

关 键 词：熊去氧胆酸 肝内外胆管结石 胆道镜 肝功能 

分 类 号：R657.4[医药卫生—外科学]