辅助应用小剂量透明质酸钠凝胶预防急性弥漫性腹膜炎患者术后粘连性肠梗阻的效果  

Effect of Small Dose of Sodium Hyaluronate Gel on Prevention of Postoperative Adhesive Intestinal Obstruction in Patients with Acute Diffuse Peritonitis

作　　者：宋子华 陈娟 SONG Zihua;CHEN Juan(Shantou Longhu District Second People’s Hospital,Shantou,Guangdong,515041)

机构地区：[1]汕头市龙湖区第二人民医院,广东汕头515041

出　　处：《智慧健康》2022年第14期93-95,共3页Smart Healthcare

基　　金：汕头市科技计划项目《急性弥漫性腹膜炎术中应用小剂量透明质酸钠凝胶预防粘连性肠梗阻的疗效观察》(项目编号:190619105268877)。

摘　　要：目的 观察小剂量透明质酸钠凝胶辅助应用对预防急性弥漫性腹膜炎患者术后粘连性肠梗阻的效果。方法 选取150例急性弥漫性腹膜炎行急诊手术患者作为研究对象,按照随机数字表法分为对照组和观察组各75例。对照组行常规病灶切除及生理盐水清洗,观察组在对照组基础上在创伤部位涂布小剂量的医用透明质酸钠凝胶,通过比较两组患者排气、切口愈合时间,以及肠粘连发生情况和两组肠梗阻发生率,来评估应用小剂量透明质酸钠凝胶的效果。结果 观察组患者术后排气时间明显早于对照组(P<0.05),两组患者切口愈合时间比较无统计秀意义(P>0.05)。观察组术后粘连性肠梗阻发生率明显低于对照组,差别具有统计学意义(P<0.05)。结论 应用小剂量透明质酸钠凝胶能够有效减轻急性弥漫性腹膜炎术后脏器粘连程度,减少粘连性肠梗阻发生率,可行性强,值得推广。Objective To explore the feasibility of using low dose sodium hyaluronate gel to prevent postoperative adhesive intestinal obstruction after acute diffuse peritonitis,and to provide a basis for clinical practice.Methods A total of 150 patients with acute diffuse peritonitis who underwent emergency surgery were selected as the research objects,and were divided into the control group and the observation group with 75 cases in accordance with the random number table method.The control group underwent routine lesion resection and normal saline cleaning,and the observation group applied a small dose of medical sodium hyaluronate gel to the wound on the basis of the control group.By comparing the two groups of patients with gas exhaust,incision healing time,and the occurrence of intestinal adhesions.The situation and the incidence of intestinal obstruction in the two groups were used to evaluate the effect of low-dose sodium hyaluronate gel.Results The postoperative exhaust time of the observation group was significantly earlier than that of the control group (P<0.05),and the incision healing time of the two groups of patients was not statistically significant (P>0.05).The incidence of postoperative adhesive intestinal obstruction in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of low-dose sodium hyaluronate gel can effectively reduce the degree of intestinal adhesions after acute diffuse peritonitis and reduce the incidence of adhesive intestinal obstruction.It is feasible and worthy of promotion.

关 键 词：透明质酸钠凝胶 小剂量 粘连性肠梗阻 急性弥漫性腹膜炎 发生率 

分 类 号：R656.4[医药卫生—外科学]