可溶性髓样细胞触发受体-1在百草枯中毒患者早期预后中的评估价值  

Evaluation Value of Soluble Myeloid Cell Trigger Receptor-1 in Early Prognosis of Patients with Paraquat Poisoning

作　　者：邱云 高素敏 吴一晨[1] QIU Yun;GAO Sumin;WU Yichen(Emergency Medicine Department,Nanjing Medical University Affiliated Huai'an the First Hospital,Huai'an,Jiangsu,223300)

机构地区：[1]南京医科大学附属淮安第一医院急诊医学科,江苏淮安223300

出　　处：《智慧健康》2022年第9期53-55,184,共4页Smart Healthcare

摘　　要：目的 研究血清可溶性髓样细胞触发受体-1(sTREM-1)对急性百草枯中毒早期评估预后的价值。方法 回顾性分析2016年1月-2020年6月南京医科大学附属淮安第一医院收治的急性百草枯中毒患者41例,收集研究对象早期一般资料,并对早期血清sTREM-1与患者急性肾损伤(AKI)、急性肺损伤(ALI)及死亡率相关性进行统计分析,实验随访至发病后30d。利用ROC曲线评估sTREM-1在中毒患者预后中的预测价值。结果 本研究纳入者平均年龄(42.8±13.1)岁,首次洗胃平均时间(1.65±0.6)h,首次血液灌流平均时间(5.02±0.77)h,总AKI发生率54%(22/41),总ALI发生率56%(23/41),总死亡率39%(16/41)。死亡患者早期血清sTREM-1较生存者明显升高,是急性百草枯中毒患者死亡的独立危险因素,ROC曲线下面积为0.9625(95% CI:0.9095-1.015)。同时,sTREM-1也是百草枯中毒患者AKI与ALI发生的独立危险因素,ROC曲线下面积分别为0.8888(95% CI:0.7902-0.9873)及0.9215(95% CI:0.8395-1.003)。结论 急性百草枯中毒患者早期血清sTREM-1的显著增高与死亡率具有相关性,同样与患者重要脏器的损伤密切相关,可以作为评估中毒预后的重要指标。Objective To study value of serum soluble myeloid cell trigger receptor-1 (sTREM-1) in early prognosis of acute paraquat poisoning.Methods The paper reviewed and analyzed early general data of 41 patients with acute paraquat poisoning treated in our hospital from January 2016 to June 2020,and statistically analyzed correlation between early serum sTREM-1 and acute renal injury (AKI),acute lung injury (ALI) and mortality.Experiment was followed up to 30 days after onset.Predictive value of sTREM-1 in prognosis of poisoning patients was evaluated with ROC curve.Results Average age of participants in the study was (42.8±13.1),average time of first gastric lavage was (1.65±0.6) hours,average time of first hemoperfusion was (5.02±0.77) hours,total incidence of AKI was 54% (22/41),total incidence of ALi was 56% (23/41),total mortality was 39% (16/41).Serum sTREM-1 at early stage of death was significantly higher than survivors,which was an independent risk factor for death of patients with acute paraquat poisoning.Area under ROC curve was 0.9625 (95% CI:0.9095-1.015).At the same time,sTREM-1 was one of independent risk factors for AKI and ALi of patients with paraquat poisoning.Areas under ROC curve were 0.8888 (95% CI:0.7902-0.9873) and 0.9215 (95% CI:0.8395-1.003) respectively.Conclusion Significant increase of serum sTREM-1 of patients with acute paraquat poisoning at early stage is related to mortality,and closely related to injury of important organs,which can be an important index to evaluate prognosis of poisoning.

关 键 词：可溶性髓样细胞触发受体-1 百草枯中毒 死亡率 急性肾损伤 急性肺损伤 

分 类 号：R595.4[医药卫生—内科学]