溴乙基二苯乙腈的合成及杂质研究  

Study on Synthesis and Impurities of Bromoethyl Diphenylacetonitrile

作　　者：袁伟 殷晓伟 杨科 李正义[1] YUAN Wei;YIN Xiaowei;YANG Ke;LI Zhengyi(Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China;Changzhou Kangpu Pharmaceutical Co., Ltd., Changzhou 213172, China)

机构地区：[1]常州大学石油化工学院江苏省绿色催化材料与技术重点实验室,江苏常州213164 [2]常州康普药业有限公司,江苏常州213172

出　　处：《合成化学》2022年第7期569-573,共5页Chinese Journal of Synthetic Chemistry

基　　金：江苏省先进催化与绿色制造协同创新中心资助项目(ACGM2019-05-08)。

摘　　要：以二苯乙腈和二溴乙烷为原料,苯扎溴铵为相转移催化剂,在氢氧化钠水溶液中高效合成溴乙基二苯乙腈。分别考察了不同相转移催化剂、碱的种类及用量、原料配比对反应收率和选择性的影响,优化反应条件,得到了溴乙基二苯乙腈的最佳合成工艺,同时实现了两种相关杂质的定向合成。溴乙基二苯乙腈2及两种相关杂质3和4的结构经^(1)H NMR,^(13)C NMR和MS(EI)确证。Bromoethyl diphenylacetonitrile was efficient synthesized from diphenylacetonitrile and dibromoethane in sodium hydroxide aqueous solution by phase transfer catalyst of benzalkonium bromide.Effects of different phase transfer catalyst,base,base dosage and raw material ratio on the yield and selectivity of the reaction were investigated.After optimized the reaction conditions,the best synthesis technology of bromoethyl diphenylacetonitrile and the ific synthesis of two impurities have been achieved.The structures of bromoethyl diphenylacetonitrile 2 and the two impurities of 3 and 4 were characterized by ^(1)H NMR,^(13)C NMR and MS(EI),respectively.

关 键 词：溴乙基二苯乙腈 合成 杂质 相转移催化 医药中间体 

分 类 号：O621.3[理学—有机化学]